Publications associées à Îlot de Langerhans

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marked reduction in insulin-producing beta-cells. The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency. RES ...

American Diabetes Association2010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Towards high resolution optical imaging of beta cells in vivo

Theo Lasser, Anne Grapin-Botton, Martin Villiger, Joan Goulley, Erica Martin-Williams

Endocrine beta cells produce and release insulin in order to tightly regulate glucose homeostasis and prevent metabolic pathologies such as Diabetes Mellitus. Optical imaging has contributed greatly to our current understanding of beta cell structure and f ...

Bentham Science Publishers2010

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

Kristina Schoonjans, Andreas Wiederkehr, Chikage Mataki

Glucose-evoked mitochondrial signals augment ATP synthesis in the pancreatic β cell. This activation of energy metabolism increases the cytosolic ATP/ADP ratio, which stimulates plasma membrane electrical activity and insulin granule exocytosis. We have re ...

2010

In vivo imaging of pancreatic endocrine islets

Theo Lasser, Christophe Pache, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Martin Villiger, Joan Goulley

Extended focus optical coherence microscope (xfOCM) circumvents the compromise between lateral resolution and depth of field by us of a Bessel-like illumination beam. The high sensitivity and parallel depth profiling of Fourier domain optical coherence tom ...

SPIE2009

In Vivo extended focus Optical Coherence Microscopy of endocrine islets of Langerhans in mice

Theo Lasser, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Martin Villiger, Joan Goulley

Rapid acquisition of volumetric data is a mandatory prerequisite for small animal in vivo imaging. Due to its high sensitivity and capacity to extract the sample depth profile in parallel Fourier Domain Optical Coherence Tomography (FDOCT) complies with th ...

2009

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Theo Lasser, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Martin Villiger, Joan Goulley

Aims/hypothesis Structural and functional imaging of the islets of Langerhans and the insulin-secreting beta cells represents a significant challenge and a long-lasting objective in diabetes research. In vivo microscopy offers a valuable insight into beta ...

Springer Verlag2009

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Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Îlot de Langerhans

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Towards high resolution optical imaging of beta cells in vivo

Wnt Signaling in Pancreas Development and Cancer

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

Extended Focus Optical Coherence Microscopy

In vivo imaging of pancreatic endocrine islets

In Vivo extended focus Optical Coherence Microscopy of endocrine islets of Langerhans in mice

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Graph Chatbot

Chattez avec Graph Search

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells

In vivo imaging of pancreatic endocrine islets

Extended Focus Optical Coherence Microscopy

In Vivo extended focus Optical Coherence Microscopy of endocrine islets of Langerhans in mice

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

Role of Neurogenin3 in migration of pancreatic endocrine cells during development

Wnt Signaling in Pancreas Development and Cancer

Towards high resolution optical imaging of beta cells in vivo

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes