Publications associées à Neurone

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that causes death of motor neurons. ALS patients and mouse models of familial ALS display organismal level metabolic dysfunction, which includes increased energy expenditure despite ...

Oxford University Press2014

The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity

Giovanni Dietler, Hilal Lashuel, Anne-Laure Mahul Mellier, Bruno Claude Daniel Fauvet, Francesco Simone Ruggeri, Abid Oueslati, Martial Mbefo Kamdem, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf, Filip Vercruysse

Over the last two decades, the identification of missense mutations in the alpha-synuclein (alpha-Syn) gene SNCA in families with inherited Parkinson disease (PD) has reinforced the central role of alpha-Syn in PD pathogenesis. Recently, a new missense mut ...

American Society for Biochemistry and Molecular Biology2014

Impact of Networked Cognition and Learning on Engineered Systems [Further Thoughts]

Ali H. Sayed

The research community is witnessing expansive efforts aimed at understanding one of the most wondrous manifestations of cognition in nature. The Blue Brain Project and the Human Brain Project in Europe are examples of ambitious drives aimed at building a ...

Institute of Electrical and Electronics Engineers2014

Measuring Symmetry, Asymmetry and Randomness in Neural Network Connectivity

Michele Giugliano, Eleni Vasilaki

Cognitive functions are stored in the connectome, the wiring diagram of the brain, which exhibits non-random features, so-called motifs. In this work, we focus on bidirectional, symmetric motifs, i.e. two neurons that project to each other via connections ...

Public Library of Science2014

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Bernard Schneider, Nicholas David James

Chondroitin sulfate proteoglycans (CSPGs) inhibit repair following spinal cord injury. Here we use mammalian-compatible engineered chondroitinase ABC (ChABC) delivered via lentiviral vector (LV-ChABC) to explore the consequences of large-scale CSPG digesti ...

Society for Neuroscience2014

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Hilal Lashuel, Nadine Aït Bouziad, Mohamed Bilal Fares, Martial Mbefo Kamdem, Ana Jovicic

A novel mutation in the alpha-Synuclein (alpha-Syn) gene "G51D" was recently identified in two familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy (MSA). In this study, we explored the impact of this novel mutation on ...

Oxford University Press2014

Noise facilitation in associative memories of exponential capacity

Mohammad Amin Shokrollahi, Amin Karbasi, Amir Hesam Salavati

Recent advances in associative memory design through structured pattern sets and graph-based inference al- gorithms have allowed reliable learning and recall of an exponential number of patterns. Although these designs correct external errors in recall, th ...

Mit Press2014

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Jean-Marie Petit, Pascal Jourdain, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

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Neurone

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis

The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity

Impact of Networked Cognition and Learning on Engineered Systems [Further Thoughts]

Measuring Symmetry, Asymmetry and Randomness in Neural Network Connectivity

Visualizing the similarity and pedigree of NEURON ion channel models available on ModelDB

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Involvement of autophagy in hypoxic-excitotoxic neuronal death

Noise facilitation in associative memories of exponential capacity

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Graph Chatbot

Chattez avec Graph Search

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Noise facilitation in associative memories of exponential capacity

Involvement of autophagy in hypoxic-excitotoxic neuronal death

The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of alpha-synuclein, and enhances its secretion and nuclear localization in cells

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

Visualizing the similarity and pedigree of NEURON ion channel models available on ModelDB

Measuring Symmetry, Asymmetry and Randomness in Neural Network Connectivity

Impact of Networked Cognition and Learning on Engineered Systems [Further Thoughts]

The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis