Concept
Paralysie
Publications associées (34)
Patient Motion Using a Computerized Leg Brace in Everyday Locomotion Tasks
Exoskeletal systems are becoming a rehabilitation standard of care for persons with lower limb paralysis. As muscular dysfunctions affect a heterogeneous patient group, each individual develops their own strategy to negotiate everyday locomotion challenges ...
2019Neuroprosthetic Technologies to Evaluate and Train Leg Motor Control in Neurologically Impaired Individuals
Camille Georgette Marie Le Goff-Mignardot
Spinal cord injury (SCI) disrupts many essential sensorimotor and autonomic functions. Consequently, individuals with SCI can face decades with permanent disabilities. Advances in clinical management have decreased morbidity, but no clinical trial has yet ...
EPFL2019Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion
Grégoire Courtine, Bernard Schneider, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Lucia Florinda Friedli Wittler, Laetitia Danielle Philippine Baud, Polina Shkorbatova, Janine Beauparlant, Galyna Pidpruzhnykova, Selin Anil, Julie Kreider, Cristina Martinez Gonzalez, Elodie Rey
Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...
2018Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord
Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Polina Shkorbatova, Nathan Antoine Greiner
Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...
2018Hybrid peripheral-spinal neuroprosthesis for refined motor execution after paralysis
Spinal cord injury (SCI) disrupts the communication between the brain and the spinal circuits responsible for movement, thereby causing severe motor deficits. Current strategies to restore function to paralyzed limbs have separately investigated electrical ...
EPFL2018Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke
José del Rocio Millán Ruiz, Hua Zhang, Robert Leeb, Inaki Asier Iturrate Gil, Serafeim Perdikis, Andrea Biasiucci, Tiffany Corbet, Thomas Schmidlin, Dragana Viceic
Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functio ...
2018A Computational Approach for the Design of Epidural Electrical Spinal Cord Stimulation Strategies to Enable Locomotion after Spinal Cord Injury
Spinal cord injury (SCI) is a major cause of paralysis with currently no effective treatment.
Epidural electrical stimulation (EES) of the lumbar spinal cord has been shown to restore locomotion in animal models of SCI, but has not yet reached the same lev ...
EPFL2018Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury
Silvestro Micera, Grégoire Courtine, Marco Bonizzato, Polina Shkorbatova, Natalia Pavlova, Galyna Pidpruzhnykova
The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practi ...
Nature Publishing Group2018Cortico-reticulo-spinal circuits mediate functional recovery after spinal cord contusion
After a spinal cord injury (SCI), only half of affected individuals regain voluntary control of leg movements below the level of the lesion. Anatomical, electrophysiological and imaging data revealed that even the most severe forms of SCI usually spare a s ...
EPFL2017Learning new movements after paralysis: Results from a home-based study
Camilla Pierella, Ismael Seanez Gonzalez, Ali Farshchiansadegh
Body-machine interfaces (BMIs) decode upper-body motion for operating devices, such as computers and wheelchairs. We developed a low-cost portable BMI for survivors of cervical spinal cord injury and investigated it as a means to support personalized assis ...
Nature Publishing Group2017