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Publications associées (80)
Essential role of Cp190 in physical and regulatory boundary formation
Nicolas Jean Philippe Guex, Julien Dorier, Christian Iseli
Boundaries in animal genomes delimit contact domains with enhanced internal contact frequencies and have debated functions in limiting regulatory cross-talk between domains and guiding enhancers to target promoters. Most mammalian boundaries form by stalli ...
2022Ribo-DT: An automated pipeline for inferring codon dwell times from ribosome profiling data
Protein synthesis is an energy consuming process characterised as a pivotal and highly regulated step in gene expression. The net protein output is dictated by a combination of translation initiation, elongation and termination rates that have remained dif ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2022Prioritization of cell types responsive to biological perturbations in single-cell data with Augur
Grégoire Courtine, Jordan Squair, Matthieu Pierre Gautier, Michael Alexander Skinnider
Advances in single-cell genomics now enable large-scale comparisons of cell states across two or more experimental conditions. Numerous statistical tools are available to identify individual genes, proteins or chromatin regions that differ between conditio ...
NATURE RESEARCH2021A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
Jacques Fellay, John Wilson, Yang Luo, Xinyi Li
A high-resolution reference panel based on whole-genome sequencing data enables accurate imputation of HLA alleles across diverse populations and fine-mapping of HLA association signals for HIV-1 host response. Fine-mapping to plausible causal variation ma ...
NATURE PORTFOLIO2021Targeted Perturb-seq enables genome-scale genetic screens in single cells
The transcriptome contains rich information on molecular, cellular and organismal phenotypes. However, experimental and statistical limitations constrain sensitivity and throughput of genetic screening with single-cell transcriptomics readout. To overcome ...
2020The functional proteome landscape of Escherichia coli
Camille Véronique Bernadette Goemans
Recent developments in high-throughput reverse genetics1,2 have revolutionized our ability to map gene function and interactions3,4,5,6. The power of these approaches depends on their ability to identify functionally associated genes, which elicit similar ...
2020