Publications associées à Acide kaïnique

A 16-Channel 1.1mm2 Implantable Seizure Control SoC with Sub-μW/Channel Consumption and Closed-Loop Stimulation in 0.18μm CMOS

Alexandre Schmid, Mahsa Shoaran, Yusuf Leblebici, Amirhossein Shahshahani, Masoud Shahshahani

We present a 16-channel seizure detection system-on-chip (SoC) with 0.92μW/channel power dissipation in a total area of 1.1mm² including a closed-loop neural stimulator. A set of four features are extracted from the spatially filtered neural data to achiev ...

IEEE2016

An Adeno-Associated Virus-Based Intracellular Sensor of Pathological Nuclear Factor-kappa B Activation for Disease-Inducible Gene Transfer

Elias Georges Gebara

Stimulation of resident cells by NF-kappa B activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system (CNS). This disease-mediated NF-kappa B activation could be used to drive transgene expression se ...

Public Library Science2013

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

Rolf Gruetter, Hongxia Lei, Malte Alf

After ischemic stroke, the ischemic damage to brain tissue evolves over time and with an uneven spatial distribution. Early irreversible changes occur in the ischemic core, whereas, in the penumbra, which receives more collateral blood flow, the damage is ...

Wiley-Blackwell2012

Photobleaching-free infrared near-field microscopy localizes molecules in neurons

Giorgio Margaritondo, Kai Johnsson, Harald Hirling, Johanna Generosi, Michel Kropf

High-resolution detection of specific molecules in cells is a major challenge in biology. We show that infrared scanning near-field microscopy can detect the spatial distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid–type glutamate r ...

2008

Cellular dynamics explored with digital holographic microscopy

Benjamin Rappaz

Obtaining high resolution 3D quantitative images is critical for elucidating the relationship between cell dynamics and physiological or pathological processes. However the feasibility of such cellular dynamic studies is limited by the resolution of the 3D ...

EPFL2008