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Innovation, industry and firm age: are there new knowledge production functions?

Gabriele Pellegrino

In this paper we investigate how the knowledge production function is at work in different industrial sectors comparing mature and young companies in Italy. We estimate a two-step model using community innovation survey data. We provide evidence that young ...

SPRINGER HEIDELBERG2020

Clothing-Mediated Exposures to Chemicals and Particles

Dusan Licina

A growing body of evidence identifies clothing as an important mediator of human exposure to chemicals and particles, which may have public health significance. This paper reviews and critically assesses the state of knowledge regarding how clothing, durin ...

2019

LTCC magnetic sensors at EPFL and TCV: Lessons learnt for ITER

Duccio Testa, Xavier Llobet, Pierre Lavanchy, Matthieu Toussaint, Ugo Siravo, Frédéric Dolizy, Jonathan Bryan Lister, Steve Couturier, Thomas Maeder, Philippe Marmillod

Innovative 3D high-frequency magnetic sensors have been designed and manufactured in-house for installation on the Tokamak a Configuration Variable (TCV), and are currently routinely operational. These sensors combine the Low Temperature Co-fired Ceramic ( ...

2019

Unexpected large evasion fluxes of carbon dioxide from turbulent streams draining the world’s mountains

Tom Ian Battin, Enrico Bertuzzo, Amber Joy Ulseth, Asa Lovisa Viktoria Horgby, Pier Luigi Segatto

Inland waters, including streams and rivers, are active components of the global carbon cycle.Despite the large areal extent of the world’s mountains, the role of mountain streams forglobal carbonfluxes remains elusive. Using recent insights from gas excha ...

Nature Research2019

Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Maurizio Molinari, Francesca Bianchi

In the peripheral nervous system (PNS) myelinating Schwann cells synthesize large amounts of myelin protein zero (P0) glycoprotein, an abundant component of peripheral nerve myelin. In humans, mutations in P0 cause the demyelinating Charcot-Marie-Tooth 1B ...

2019

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke

Silvestro Micera, Stefano Lai, Francesco Saverio Pavone

Rehabilitation is considered the most effective treatment for promoting the recovery of motor deficits after stroke. One of the most challenging experimental goals is to unambiguously link brain rewiring to motor improvement prompted by rehabilitative ther ...

2019

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor

Carlos Canto Alvarez, Richardus Houtkooper, Sofia Moco

Objective: A decay in intracellular NAD(+) levels is one of the hallmarks of physiological decline in normal tissue functions. Accordingly, dietary supplementation with NAD(+) precursors can prevent, alleviate, or even reverse multiple metabolic complicati ...

2019

More Than Black or White: Melanization and Toll Share Regulatory Serine Proteases in Drosophila

Bruno Lemaitre, Jan Paul Dudzic, Mark Austin Hanson, Igor Iatsenko

The melanization response is an important defense mechanism in arthropods. This reaction is mediated by phenoloxidases (POs), which are activated by complex extracellular serine protease (SP) cascades. Here, we investigate the role of SPs in the melanizati ...

2019

Governance of Trust in Precision Medicine

Marie-Valentine Renée Agnès Florin, Kujtesë Bejtullahu Michalopoulos

Following up a two-day invitation-only expert workshop in Geneva on the subject of Trust and Precision Medicine, IRGC published a workshop report in April 2018. This report addresses the concept of trust and conditions of trustworthiness in each of the thr ...

EPFL International Risk Governance Center2018

Breaking size-segregation waves and mobility feedback in dense granular avalanches

Christophe Ancey, Kasper van der Vaart

Through experiments and discrete particle method (DPM) simulations we present evidence for the existence of a recirculating structure, that exists near the front of dense granular avalanches, and is known as a breaking size-segregation (BSS) wave. This is ...

2018

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Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice

Maurizio Molinari, Francesca Bianchi

2019

A reduced form of nicotinamide riboside defines a new path for NAD(+) biosynthesis and acts as an orally bioavailable NAD(+) precursor

Carlos Canto Alvarez, Richardus Houtkooper, Sofia Moco

2019

Combined Rehabilitation Promotes the Recovery of Structural and Functional Features of Healthy Neuronal Networks after Stroke

Silvestro Micera, Stefano Lai, Francesco Saverio Pavone

2019

Breaking size-segregation waves and mobility feedback in dense granular avalanches

Christophe Ancey, Kasper van der Vaart

2018