Publications associées à Phosphoinositide 3-kinase

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Liliane Glauser, Elpida Tsika, Darren Moore, Klodjan Stafa, Amy Jones, Alessandra Musso

Mutations in LRRK2 cause autosomal dominant Parkinsons disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative proteinprotein interaction domains. Familial PD mutations alter the GTPase and kinase activity of L ...

Oxford University Press2014

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility

Sandrine Madeleine Suzanne Georgeon, Oliver Hantschel, Allan Joaquim Lamontanara

The activity of protein kinases is regulated by multiple molecular mechanisms, and their disruption is a common driver of oncogenesis. A central and almost universal control element of protein kinase activity is the activation loop that utilizes both confo ...

2014

Mechanisms of resistance to BCR-ABL and other kinase inhibitors

Oliver Hantschel, Allan Joaquim Lamontanara, Emel Basak Gencer Akçok, Orest Kuzyk

In this article, we are reviewing the molecular mechanisms that lead to kinase inhibitor resistance. As the oncogenic BCR-ABL kinase is the target of the first approved small-molecule kinase inhibitor imatinib, we will first focus on the structural and mec ...

Elsevier Science Bv2013

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

Hilal Lashuel, Patrick Aebischer, Bernard Schneider, Abid Oueslati

An increase in α-synuclein levels due to gene duplications/triplications or impaired degradation is sufficient to trigger its aggregation and cause familial Parkinson disease (PD). Therefore, lowering α-synuclein levels represents a viable therapeutic stra ...

National Academy of Sciences2013

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking

Georgios Sflomos

Smad anchor for receptor activation (SARA) is highly enriched on endocytic membranes via binding to phosphatidylinositol 3-phosphates through its FYVE (Fab1p-YOTB-Vps27p-EEA1) domain. SARA was originally identified as a protein that recruits non-phosphoryl ...

Nature Publishing Group2013

Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease

Elpida Tsika, Darren Moore, Alzbeta Trancikova

Mitochondria are highly dynamic, multifunctional organelles. Aside from their major role in energy metabolism, they are also crucial for many cellular processes including neurotransmission, synaptic maintenance, calcium homeostasis, cell death, and neurona ...

2012

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Hubert van den Bergh, Patrycja Nowak-Sliwinska, Blaise Lovisa

Targeted angiostatic therapy receives major attention for the treatment of cancer and exudative age-related macular degeneration (AMD). Photodynamic therapy (PDT) has been used as an effective clinical approach for these diseases. Since PDT can cause an an ...

2012

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1

Viesturs Simanis

Mitotic exit integrates the reversal of the phosphorylation events initiated by mitotic kinases with a controlled cytokinesis event that cleaves the cell in two. The mitotic exit network (MEN) of budding yeast regulates both processes, whereas the fission ...

Nature Publishing Group2012

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Phosphoinositide 3-kinase

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility

Phosphatidylinositol-4-phosphate: The Golgi and beyond

Mechanisms of resistance to BCR-ABL and other kinase inhibitors

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking

Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease

Distinct Spatial and Molecular Features of Notch Pathway Assembly in Regulatory T Cells

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1

Graph Chatbot

Chattez avec Graph Search

Phosphatidylinositol-4-phosphate: The Golgi and beyond

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

The S-pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

The SH2 domain of Abl kinases regulates kinase autophosphorylation by controlling activation loop accessibility

Mechanisms of resistance to BCR-ABL and other kinase inhibitors

Angiostatic kinase inhibitors to sustain photodynamic angio-occlusion

Distinct Spatial and Molecular Features of Notch Pathway Assembly in Regulatory T Cells

SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking

Mitochondrial Dysfunction in Genetic Animal Models of Parkinson's Disease