Concept

Carcinome spinocellulaire

Publications associées (100)

Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors

We are now witnessing a resurgence of theories of development and carcinogenesis in which the environment is again being accepted as a major player in phenotype determination. Perturbations in the fetal environment predispose an individual to disease that ...

Springer Verlag2013

Fibronectin Binding Modulates CXCL11 Activity and Facilitates Wound Healing

Marco Pisano, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Federico Tortelli

Engineered biomatrices offer the potential to recapitulate the regenerative microenvironment, with important implications in tissue repair. In this context, investigation of the molecular interactions occurring between growth factors, cytokines and extrace ...

Public Library of Science2013

ZrNO-Ag co-sputtered surfaces leading to E. coli inactivation under actinic light: Evidence for the oligodynamic effect

César Pulgarin, Juan Kiwi, Michaël Bensimon, Sami Rtimi, Rosendo Sanjines, Mirela Pascu

This study reports visible light sensitive ZrNO and ZrNO-Ag polyester samples prepared by sputtering in an Ar/N-2/O-2 atmosphere leading to Escherichia coil bacterial inactivation. The bacterial inactivation by ZrNO avoids the increasing environmental conc ...

Elsevier2013

Carcinogen treatment in mouse selectively expressing activated N-Ras(Q61K) in melanocytes recapitulates metastatic cutaneous melanoma development

Friedrich Beermann

The incidence of melanoma has significantly increased and a better understanding its pathogenesis and development of new therapeutic strategies are urgently needed. Here we describe a murine model of metastatic cutaneous melanoma using C57BL/6 mice express ...

2012

Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma

Yann Barrandon, Friedrich Beermann, Stéphanie Claudinot, Lukas Sommer

Giant congenital naevi are pigmented childhood lesions that frequently lead to melanoma, the most aggressive skin cancer. The mechanisms underlying this malignancy are largely unknown, and there are no effective therapies. Here we describe a mouse model fo ...

Nature Publishing Group2012

Innovative TiO2/Cu Nanosurfaces Inactivating Bacteria in the Minute Range under Low-Intensity Actinic Light

César Pulgarin, Juan Kiwi, Sami Rtimi, Rosendo Sanjines, Oualid Baghriche

The bacterial inactivation of E. coli by cotton TiO2/Cu DC-magnetron sputtered thin films was investigated in the dark and under low-intensity actinic light. The TiO2/Cu sputtered layers revealed to be sensitive to actinic light showing the spectral charac ...

Amer Chemical Soc2012

Real-time, in vivo measurement of tissular pO(2) through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy

Hubert van den Bergh, Georges Wagnières, Anna Maria Novello, Patrycja Nowak-Sliwinska, Filippo Piffaretti, Cédric Xavier Paulou

Tissular oxygen concentration plays a key role during photodynamic therapy (PDT). Therefore, monitoring its local oxygen partial pressure (pO(2)) may help predict and/or control the outcome of a PDT treatment. The first real-time, in vivo measurements of t ...

Spie-Soc Photo-Optical Instrumentation Engineers2012

Protein-Binding Microarray Analysis of Tumor Suppressor AP2 alpha Target Gene Specificity

Horst Vogel, Luigino Grasso, Jan Kerschgens, Tanja Egener-Kuhn, Nicolas Mermod, Hans-Anton Lehr

Cheap and massively parallel methods to assess the DNA-binding specificity of transcription factors are actively sought, given their prominent regulatory role in cellular processes and diseases. Here we evaluated the use of protein-binding microarrays (PBM ...

Public Library of Science2011

Effects of Photodynamic Therapy in Combination with Anti-Angiogenic Drugs on the Chicken Chorioallantoic Membrane Model

Photodynamic therapy (PDT) is clinically-approved in the treatment of angiogenic disorders, particularly eye diseases such as age-related macular degeneration (AMD) and skin cancers, such as basal cell carcinoma. PDT causes vascular occlusion resulting in ...

2011

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Paloma Ordonez Moran

BACKGROUND: Cyclooxygenase-2 (COX-2) overexpression in colorectal cancer increases levels of its pro-tumorigenic product prostaglandin E2 (PGE(2)). The recently identified colorectal tumour suppressor 15-prostaglandin dehydrogenase (15-PGDH) catalyses pros ...

BMJ Publishing Group2011

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