Felix SchürmannFelix Schürmann is co-director of the Blue Brain Project and involved in several research challenges of the European Human Brain Project. He studied physics at the University of Heidelberg, Germany, supported by the German National Academic Foundation. Later, as a Fulbright Scholar, he obtained his Master's degree (M.S.) in Physics from the State University of New York, Buffalo, USA, under the supervision of Richard Gonsalves. During these studies, he became curious about the role of different computing substrates and dedicated his master thesis to the simulation of quantum computing. He studied for his Ph.D. at the University of Heidelberg, Germany, under the supervision of Karlheinz Meier. For his thesis he co-designed an efficient implementation of a neural network in hardware.
Caroline KarmannCaroline Karmann is a PostDoctoral Researcher at the Laboratory of Integrated Performance in Design (LIPID) in the Swiss Federal Institute of Technology, Lausanne (EPFL). Caroline is interested in architecture and daylight in spaces, and in how our built environments affect our well-being. Her current research lies in the gap between visual comfort and visual interests based on the subjective and behavioral responses of occupants.
Caroline holds PhD in Building Science in Architecture from UC Berkeley and a dual Master’s degree in Architecture and Energy Engineering from INSA Strasbourg. Her doctoral project was devoted to indoor environmental quality in buildings using radiant conditioning systems. She conducted full-scale laboratory experiments and fields studies in 20 buildings. Her work was presented in multiple conferences including the ASHRAE conference, Windsor and PLEA, where she won Best Paper Award in 2018.
Caroline has five years of professional experience in the field of climate responsive building design. She worked as a consultant for daylight and energy at Transsolar (Stuttgart), where she specialized in building performance simulation, in particular daylighting simulation. Following her PhD, she worked for one year at Arup (London), where she conducted research on city resilience, and supported research activities through workshop facilitation and strategic planning.
Mario PaoloneMario Paolone received the M.Sc. (with honors) and the Ph.D. degree in electrical engineering from the University of Bologna, Italy, in 1998 and 2002, respectively. In 2005, he was appointed assistant professor in power systems at the University of Bologna where he was with the Power Systems laboratory until 2011. In 2010, he received the Associate Professor eligibility from the Politecnico di Milano, Italy. Since 2011 he joined the Swiss Federal Institute of Technology, Lausanne, Switzerland, where he is now Full Professor, Chair of the Distributed Electrical Systems laboratory and Head of the Swiss Competence Center for Energy Research (SCCER) FURIES (Future Swiss Electrical infrastructure). He was co-chairperson of the technical programme committees of the 9th edition of the International Conference of Power Systems Transients (IPST 2009) and of the 2016 Power Systems Computation Conference (PSCC 2016). He was chair of the technical programme committee of the 2018 Power Systems Computation Conference (PSCC 2018). In 2013, he was the recipient of the IEEE EMC Society Technical Achievement Award. He was co-author of several papers that received the following awards: best IEEE Transactions on EMC paper award for the year 2017, in 2014 best paper award at the 13th International Conference on Probabilistic Methods Applied to Power Systems, Durham, UK, in 2013 Basil Papadias best paper award at the 2013 IEEE PowerTech, Grenoble, France, in 2008 best paper award at the International Universities Power Engineering Conference (UPEC). He was the founder Editor-in-Chief of the Elsevier journal Sustainable Energy, Grids and Networks and was Associate Editor of the IEEE Transactions on Industrial Informatics. His research interests are in power systems with particular reference to real-time monitoring and operation, power system protections, power systems dynamics and power system transients. Mario Paolone is author or coauthor of over 300 scientific papers published in reviewed journals and international conferences.
Fernando Porté AgelFERNANDO PORTÉ AGEL Professor Director, Wind Engineering and Renewable Energy Laboratory (WIRE) School of Architecture, Civil and Environmental Engineering (ENAC) École Polytechnique Fédérale de Lausanne (EPFL) e-mail: fernando.porte-agel@epfl.ch RESEARCH INTERESTS Environmental fluid mechanics. Computational fluid dynamics. Atmospheric boundary layers. Turbulence. Large-eddy simulation. Wind energy. Wind engineering. Renewable energy. EDUCATION Ph.D. 1999 Johns Hopkins University, Environmental Engineering M.Sc. 1995 Hydrologic Engineering, IHE - Delft, The Netherlands B.S. 1992 Universidad Politécnica de Cataluña, Spain ACADEMIC POSITIONS 2010-present: Full Professor, School of Architecture, Civil and Environmental Engineering (ENAC), École Polytechnique Fédérale de Lausanne (EPFL), Switzerland 2005-2009: Associate Professor, St. Anthony Falls Laboratory and Department of Civil Engineering, University of Minnesota, Minneapolis, MN, USA 2000-2005: Assistant Professor, St. Anthony Falls Laboratory, Department of Civil Engineering, University of Minnesota, Minneapolis, MN, USA AWARDS AND FELLOWSHIPS McKnight Presidential Fellow (2006-2009), University of Minnesota, USA McKnight Land-Grant Professorship (2003-2005), University of Minnesota, USA NASA Young Investigator Award (2001-2004), USA NSF CAREER Award (2001-2006), (Division of Earth Sciences Hydrological Sciences), USA Outstanding Student Paper Award: Hydrology Section, Fall Meeting of the American Geophysical Union; San Francisco, 1998. Research Award (1995-1997): La Caixa fellowship program; Barcelona, Spain. Research Award (1993-1995): Dutch Ministry of Foreign Affairs fellowship. Research Award (1990-1993): Spanish Civil Engineering Association. Yves WeinandBiography
Architect and civil engineer, Prof. Dr. Yves Weinand is one of the most recognised researchers in the field of contemporary wood construction. Founder of the Bureau d'Etude Weinand, he has, since 1996, designed and worked on many emblematic wooden buildings, such as the Saint Loup Chapel, the new Vaudois Parliament or, more recently, the Timber Pavilion of Vidy in Lausanne. His fundamental research questions the technical and static possibilities of wooden materials. The interdisciplinary exploration carried out at the EPFL's Laboratory for Timber Constructions (Ibois), of which he is director, concerns wood in all its aspects, from round wood to manufactured wood. The recent research carried out at Ibois on free structures with wood-wood connections (without screw nor glue) has been the subject of several technological transfers, and stands as tangible proof of new possibilities for wood construction. Yves Weinand is currently working on a large-scale project for a hall for the head office of a joinery in Luxembourg, consisting of a succession of arches with spans of 22.5 to 53.7m, entirely assembled in wood ). Through new innovative approaches, the ambition of his research is to develop a new generation of renewable and ecological wooden construction.He is regularly invited to present his work at international symposia on timber construction.
Fields of expertise
Architectural designTimber structuresDigital FabricationRobotic AssemblyStructural Wood mechanicsIntegrally Attached Timber plate structures
Distinctions
2012 Grand Prix d'Architecture de Wallonie
2014 Best Paper Award, Advances in Architectural Geometry conference. (IBOIS team)
2017 Medal for Research and Technique by the Academy of Architecture. 2018 Mention Régionale, Prix Lignum for the Timber Pavilion of Vidy-Lausanne
2019 "Disctinction Bois 2019" for the Nouveau Parlement vaudois.2019 Grand Prix d'Architecture de Wallonie____________________________________________________________________________
Selected publications
Les Cahiers de l'Ibois/ Ibois Notebooks 1, F. Fromonot, S. Berthier, Y. Rocher, publication directors: Y. Weinand et C. Catsaros, 2020 EPFL Press Le Pavillon en bois du Théâtre de Vidy, under the direction of Yves Weinand; V. Baudriller, J. Gamerro, M. Jaccard, C. Robeller; 2017, PPURAdvanced Timber Structures - Architectural Designs and Digital Dimensioning, Y. Weinand, 2017, Birkhaüser, publié en trois langues (french : Structures Innovantes en Bois (2016); german : Neue Holztragwerke - Architektonische Entwürfe und digitale Bemessung (2017)Grubenmann Project / Projekt Grubenmann, Y. Weinand, 2016, Stiftung Grubenmann-SammlungTimber Project: Nouvelles formes d’architectures en bois, Y. Weinand, 2010, PPURArchitexto, Y. Weinand and D. Darcis, 2009, Editions Fourre-Tout, LiègeLe bois soudé, B. Stamm and Y. Weinand, 2004, Architecture Bois & DépendanceNew Modeling - projeter ensemble, Y. Weinand, 2003, PPUR Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.