Lobe temporal | EPFL Graph Search

vignette|droite|Animation tridimensionnelle du cerveau humain montrant le lobe temporal gauche en rouge à l'intérieur d'un crâne rendu transparent. L'hémisphère cérébral droit n'est pas montré afin de mieux mettre en valeur le gauche. Le lobe temporal est une région du cerveau des vertébrés située derrière l'os temporal (l'os situé derrière les tempes), dans la partie latérale et inférieure du cerveau. Chez l'Homme, c'est une zone importante pour de nombreuses fonctions cognitives, dont l'audition, le langage, la mémoire et la vision des formes complexes. Anatomie vignette|droite|Les lobes externes du cerveau humain. Sont aussi dessinés le cervelet en bleu et le tronc cérébral en noir qui sont des structures nerveuses distinctes du cerveau proprement dit. Les lobes temporaux sont situés à l'arrière des lobes frontaux et au-dessous des lobes pariétaux. Le sillon latéral (ancienne scissure de Sylvius) en constitue la frontière. En arrière du lobe temporal se trouve le lo

Engineering Parallel Transmit/Receive Radio-Frequency Coil Arrays for Human Brain MRI at 7 Tesla

Jérémie Daniel Clément

Magnetic resonance imaging is widely used in medical diagnosis to obtain anatomical details of the human body in a non-invasive way. Clinical MR scanners typically operate at a static magnetic field strength (B0) of 1.5T or 3T. However, going to higher field is of great interest since the signal-to-noise ratio is proportional to B0. Therefore, higher image resolution and better contrast between the human tissues could be achieved. Nevertheless, new challenges arise when increasing B0. The wavelength associated with the radio-frequency field B1+ has smaller dimensions - approx. 12 cm for human brain tissues - than the human brain itself (20 cm in length), the organ of interest in this thesis. The main consequence is that the transmit field distribution pattern (B1+) is altered and the final MR images present bright and dark signal spots. These effects prevent the ultra-high field MR scanners (>= 7T) to be used for routine clinical diagnosis. Parallel-transmit is one approach to address these new challenges. Instead of using an RF coil connected to a single power input as it is commonly done at lower magnetic fields, multiple RF coils are used with independent power inputs. The subsequent distinct RF signals can be manipulated separately, which provides an additional degree of freedom to generate homogeneous B1+-field distributions over large or specific regions in the human body. A transmit/receive RF coil array optimized for whole-brain MR imaging was developed and is described in this thesis. Dipoles antennas were used since they could provide a large longitudinal (vertical axis-head to neck) coverage and high transmit field efficiency. Results demonstrated a complete coverage of the human brain, and particularly high homogeneity over the cerebellum. However, since the receive sensitivity over large field-of-views is related to the number of channels available to detect the NMR signal, the next work was to add a 32-channel receive loop coil array to the transmit coil array. The complete coverage of the human brain was assessed with a substantial increase in signal-to-noise compared to the transmit/receive dipole coil array alone. Moreover, acquisition time was shortened since higher acceleration factors could be used. To optimize the individual RF fields and generate an homogeneous B1+-field, a method was developed making use of the particle-swarm algorithm. A user-friendly graphical interface was implemented. Good homogeneity could be achieved over the whole-brain after optimization with the coil array built in this study. Moreover, the optimization was shown to be robust across multiple subjects. The last project was focused on the single transmit system. Local volume coils (single transmit) present pronounced transmit field inhomogeneities in specific regions of the human brain such as the temporal lobes. A widely used approach to address locally these challenges is to add dielectric pads inside the volume coils to enhance the local transmit field efficiency. It was shown in this thesis that constructing dedicated surface coils is a valuable alternative to the dielectric pads in terms of transmit field efficiency and MR spectroscopy results. Two RF coil setups were developed for the temporal and frontal lobes of the human brain, respectively. This thesis provides extensive insight on MR engineering of RF coils at ultra-high field and the potential of parallel-transmit to address the future needs in clinical applications.

EPFL2019

A dynamical systems approach to synaptic consolidation and associations of concepts in hippocampus

Chiara Gastaldi

In the present work, we approach two key aspects of memory formation: associative memory and synaptic consolidation. The storage of associative memory is commonly related to the medial temporal lobe in humans. Experimental evidence shows that the memories of objects, people or places are represented in this brain area by cell assemblies that respond selectively to single concepts. Neurons forming such assemblies are called concept cells. Associations between different concepts are linked to concept cells shared between assemblies: we refer to the number of shared neurons as the overlap between memory engrams. The respective assemblies of two associated concepts (e.g. Hillary and Bill Clinton) share more neurons compared to the assemblies of two unrelated concepts (e.g. Hillary Clinton and the Eiffel tower). In particular, three characteristics of assemblies of concept cells are important for this work: (a) they exhibit a very low mean activity (about 0.2% of neurons respond to each concept), (b) overlapping assemblies share about 4% of their cells, (c) non-overlapping assemblies share less then 1% of their cells. This implies that the association between two concepts induces a higher level of overlap between the relative memory engrams. In parallel, theoretical studies have shown that overlaps between memory engrams are fundamental in the process of free recall of sequences of words. These models assume that memory engrams have such a high mean activity that all assemblies are overlapping to a certain extent. Associative memory is traditionally modeled through attractor neural networks. Memory engrams are represented by binary patterns of active/silent neurons. While there is extensive literature on independent low-activity patterns, only a few studies can be found on correlated patterns. Extending the existing theory to include correlation is a key missing point to answer questions such as: How do shared neurons encode association? Why are 4% of neurons shared and not more? Using a mean-field approximation, we derive analytic equations for the network dynamics in the case of correlated patterns. Our results provide a theoretical framework that can explain the experimentally observed value of shared neurons. We find that for concepts represented by realistically sparse neural assemblies there are a minimal and a maximal fraction of shared neurons so that associations can be reliably coded. In the presence of a periodically modulated signal, such as hippocampal oscillations, chains of associations can be recalled analogously to theories of free recall of lists of memorized words. Finally, we compare the predicted number of concepts a neuron responds to with experimental data. We test different ways of constructing correlated patterns and confirmed the common opinion that information in the hippocampus is non-hierarchically organised. In the second part of the thesis, we propose a model of synaptic consolidation based on two coupled dynamical variables: the fast synaptic weights and a slow internal synaptic mechanism. In classical experiments, the consolidation of the synapse is related to the stimulation frequency and number of repetitions. We show that it is exactly the time scale separation between the dynamics of the two variables that determines which combination of stimulation amplitude and frequency are suitable to elicit synaptic consolidation.

EPFL2021

An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

Erick Jorge Canales Rodriguez, Wenhao Jiang

Background Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample. Method To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls. Results The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression. Conclusion These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.