Douleur abdominale

Résumé

Une douleur abdominale (ou mal de ventre) peut être l'un des symptômes associés à des troubles passagers ou à une maladie grave. Établir un diagnostic définitif de la cause des douleurs abdominales d'un patient peut être assez difficile, vu le nombre de maladies susceptibles de comporter ce symptôme. Introduction Une douleur abdominale est traditionnellement décrite par sa chronicité (aiguë ou chronique), son évolution au cours du temps, sa nature (modérée, intense, coliques), sa distribution (par diverses méthodes, telles le quadrant abdominal — quadrant supérieur gauche, quadrant inférieur gauche, quadrant supérieur droit, quadrant inférieur droit — ou d'autres méthodes qui divisent l'abdomen en neuf sections), et par la caractérisation des facteurs qui l'aggravent ou la rendent moins importante. Approches Vu les divers systèmes d'organes représentés dans l'abdomen, une douleur abdominale concernera le médecin généraliste, les chirurgiens, les internistes,

Source officielle

https://fr.wikipedia.org/wiki/Douleur_abdominale

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A Light Formulation of the E* Interpolated Path Replanner

Roland Philippsen

The E* algorithm is a path planning method capable of dynamic replanning and user-configurable path cost interpolation, it results in more appropriate paths during gradient descent. The underlying formulation is based on interpreting navigation functions as a sampled continuous crossing-time map that takes into account a risk measure. Replanning means that changes in the environment model can be repaired to avoid the expenses of complete planning. This helps compensating for the increased computational effort required for interpolation.

2006

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Transcatheter arterial chemo-embolization (TACE) is a therapeutic procedure to treat primary and metastatic liver cancer. It requires prior delineation of the hepatic arteries on magnetic resonance angiography (MRA) data and identification of the vessels supplying the tumor. Manual segmentation is extremely challenging and time consuming, thereby increasing the risk of wrongfully identifying the feeding vessels. We present a vascular path planning tool for TACE procedures by automatically segmenting the hepatic arteries on MRA. The proposed method first detects the celiac trunk from the aorta, then localizes and tags bifurcations throughout the arterial network for path planning. The algorithm is based on a multiple hypothesis tracking approach used to propagate deformable mesh surfaces. We validated the proposed framework on 20 liver-cancer-patients using abdominal MRA with 20 seconds delay after contrast injection. We show that the algorithm improves the selectivity of the arterial segments and outperforms two state-of-the-art methods with respect to manual segmentation, yielding mesh geometries with a mean absolute distance of 0.61 ± 0.10 mm for 3D mesh models.

IEEE2016

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever, and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevated risk of stroke, however, can limit their use and exploration in new indications. Here we report a facile method to prepare well-defined amphiphilic diblock copolymer NSAID prodrugs by direct reversible addition-fragmentation transfer (RAFT) polymerization of the acrylamide derivative of ibuprofen (IBU), a widely used NSAID. The synthesis and self-assembling behavior of amphiphilic diblock copolymers (PEG-PIBU) having a hydrophilic poly(ethylene glycol) block and a hydrophobic IBU-bearing prodrug block were investigated Release profiles of IBU from the micelles by hydrolysis were evaluated. Furthermore, the antiproliferative action of the IBU-containing micelles in human cervical carcinoma (HeLa) and murine melanoma (B16-F10) cells was assessed.

Amer Chemical Soc2013

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