Concept

Viral entry

Publications associées (50)

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Virus removal and inactivation by iron (hydr)oxide-mediated Fenton-like processes under sunlight and in the dark

Tamar Kohn, Jessica Ivana Nieto Juarez

Advanced oxidation processes (AOPs) have emerged as a promising alternative to conventional disinfection methods to control microbial water quality, yet little is known about the fate of viruses in such processes. In this study, we investigated the fate of ...

Royal Society of Chemistry2013

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HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence ...

Elife Sciences Publications Ltd2013

Host cell entry of vaccinia virus, the prototypic poxvirus, involves a membrane fusion event delivering the viral core and two proteinaceous lateral bodies (LBs) into the cytosol. Uncoating of viral cores is poorly characterized, and the composition and fu ...

Elsevier BV2013

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Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

Polyvalent Side Chain Peptide-Synthetic Polymer Conjugates as HIV-1 Entry Inhibitors

Harm-Anton Klok, Maarten Danial

This report describes the synthesis and properties of a series of polyvalent side chain peptide synthetic polymer conjugates designed to block the CD4 binding site on gp120 and inhibit HIV-1 entry into a host cell. The peptide sequences in the conjugates a ...

2012

Three dimensional morphology of rabies virus studied by cryo-electron tomography

Paul Guichard

The rabies virus (RABV) continues to be a worldwide health problem. RABV contains a single-stranded RNA genome that associates with the nucleoprotein N. The resulting ribonucleoprotein complex is surrounded by matrix protein M, lipid bilayer and glycoprote ...

2011

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

Didier Trono, Pierre Maillard, Olivier Michielin

The tropism of retroviruses relies on their ability to exploit cellular factors for their replication as well as to avoid host-encoded inhibitory activities such as TRIM5α. N-tropic murine leukemia virus is sensitive to human TRIM5α (huTRIM5α) restriction, ...

American Society for Biochemistry and Molecular Biology2010

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

Etienne Meylan

The outcome of a viral infection depends on the interplay between the host's capacity to trigger potent antiviral responses and viral mechanisms that counteract them. Although Toll-like receptor (TLR)-3, which recognizes virally derived double-stranded (ds ...

Nature Publishing Group2008

Recombinant Adeno-Associated viral vectors are deficient in provoking a DNA damage response

Peter Martin Beard, Michail Fragkos

Adeno-associated virus type 2 (AAV2) provokes a DNA damage response that mimics a stalled replication fork. We have previously shown that this response is dependent on ataxia telangiectasia-mutated and Rad3- related kinase and involves recruitment of DNA r ...

2008

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

Didier Trono, Priscilla Turelli, Séverine Reynard, Pierre Maillard

TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction. Our resu ...

Public Library of Science2007