Concept
Récepteur sérotoninergique
Publications associées (36)
Combining robotics with enhanced serotonin-driven cortical plasticity improves post-stroke motor recovery
Silvestro Micera, Stefano Lai, Maria Pasquini, Sara Conti, Marco Mainardi
Despite recent progresses in robotic rehabilitation technologies, their efficacy for post-stroke motor recovery is still limited. Such limitations might stem from the insufficient enhancement of plasticity mechanisms, crucial for functional recovery. Here, ...
PERGAMON-ELSEVIER SCIENCE LTD2021Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes
Nako Nakatsuka, Dmitry Momotenko
The serotonergic system in the human brain modulates several physiological processes, and altered serotonergic neurotransmission has been implicated in the neuropathology of several psychiatric disorders. The study of serotonergic neurotransmission in psyc ...
2021Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...
AMER PHYSIOLOGICAL SOC2019Optimisation of aqueous synthesis of iron oxide nanoparticles for biomedical applications
Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin
Iron oxide nanoparticles (IONPs) were prepared via aqueous synthesis which combines alkaline co-precipitation (CP) of ferric and ferrous precursors with mild hydrothermal (HT) treatment without cupping agents (CA). In this novel synthesis route, CP + HT, w ...
Springer Verlag2016A Gating Mechanism of the Serotonin 5-HT3 Receptor
Our recently solved high-resolution structure of the serotonin 5-HT3 receptor (5-HT3R) delivered the first detailed structural insights for a mammalian pentameric ligand-gated ion channel. Based on this structure, we here performed a total of 2.8-μs all-at ...
Cell Press2016Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor
G-protein-coupled receptors (GPCRs) are involved in a wide range of physiological processes, and they have attracted considerable attention as important targets for developing new medicines. A central and largely unresolved question in drug discovery, whic ...
Wiley-Blackwell2016The electrophysiological effects of the serotonin 1A receptor agonist buspirone in emotional face processing
Emotional face processing is critically modulated by the serotonergic system, and serotonin (5-HT) receptor agonists impair emotional face processing. However, the specific contribution of the 5-HT1A receptor remains poorly understood. Here we investigated ...
Elsevier Science Bv2015Natural compounds boldine and menthol are antagonists of human 5-HT
Background Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bow ...
2014X-ray structure of the mouse serotonin 5-HT3 receptor
Horst Vogel, Henning Paul-Julius Stahlberg, Rudolf Hovius, Cédric Deluz, Luigino Grasso, Romain Wyss, Ghérici Hassaïne, Menno Berend Tol
Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast neurotransmission throughout the nervous system. The molecular processes of neurotransmitter binding, subsequent opening of the ion channel and ion permeation remain poorly un ...
Nature Publishing Group2014Thermal Unfolding of a Mammalian Pentameric Ligand-gated Ion Channel Proceeds at Consecutive, Distinct Steps
Horst Vogel, Henning Paul-Julius Stahlberg, Cédric Deluz, Ghérici Hassaïne, Menno Berend Tol
Pentameric ligand-gated ion channels (LGICs) play an important role in fast synaptic signal transduction. Binding of agonists to the beta-sheet-structured extracellular domain opens an ion channel in the transmembrane alpha-helical region of the LGIC. How ...
Amer Soc Biochemistry Molecular Biology Inc2013