Concept

Newborn screening

Publications associées (70)

Graphene nanowalls for high-performance chemotherapeutic drug sensing and anti-fouling properties

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki, Nima Aliakbarinodehi

Improved sensitivity and continuous monitoring of therapeutic compounds are two of the most highlighted concerns for the treatment of malignant diseases, such as cancer. We demonstrated ultrasensitive screening of etoposide, a therapeutic compound widely-u ...

2018

A microfluidics platform for combinatorial drug screening on cancer biopsies

Christoph Merten

Screening drugs on patient biopsies from solid tumours has immense potential, but is challenging due to the small amount of available material. To address this, we present here a plug-based microfluidics platform for functional screening of drug combinatio ...

2018

Non-target screening to trace ozonation transformation products in a wastewater treatment train including different post-treatments

Urs von Gunten, Juliane Hollender

Ozonation and subsequent post-treatments are increasingly implemented in wastewater treatment plants (WWTPs) for enhanced micropollutant abatement. While this technology is effective, micro pollutant oxidation leads to the formation of ozonation transforma ...

2018

Memristive Aptasensors for Theranostics

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki, Nima Aliakbarinodehi

A new application in the nano-biosensing field gives proof that the coupling of nanofabricated wires exhibiting mem- ristive electrical characteristics and DNA-aptamers, may provide definitely innovative nano-bio-sensors for ultrasensitive label-free detec ...

2017

Stealth Assessment in ITS - A Study for Developmental Dyscalculia

Intelligent tutoring systems are adapting the curriculum to the needs of the student. The integration of stealth assessments of student traits into tutoring systems, i.e. the automatic detection of student characteristics has the potential to refine this a ...

2016

Nitroarenes as Antitubercular Agents: Stereoelectronic Modulation to Mitigate Mutagenicity

Joao Pedro De Almeida Neres

Nitroarenes are less preferred in drug discovery due to their potential to be mutagenic. However, several nitroarenes were shown to be promising antitubercular agents with specific modes of action, namely, nitroimidazoles and benzothiazinones. The nitro gr ...

Wiley-V C H Verlag Gmbh2016

Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces

Paolo De Los Rios, Giuseppe Foffi, Francesco Piazza

In this paper we introduce a fully flexible coarse-grained model of immunoglobulin G (IgG) antibodies parametrized directly on cryo-EM data and simulate the binding dynamics of many IgGs to antigens adsorbed on a surface at increasing densities. Moreover, ...

Public Library Science2016

Ultrafast Band Structure Control of a Two-Dimensional Heterostructure

Jens Christian Johannsen

The electronic structure of two-dimensional (2D) semiconductors can be significantly altered by screening effects, either from free charge carriers in the material or by environmental screening from the surrounding medium. The physical properties of 2D sem ...

Amer Chemical Soc2016

Thermal Stability Predictions for Inherently Safe Process Design Using Molecular-Based Modelling Approaches

Thierry Meyer, Annik Nanchen, Francis Stoessel, Nadia Baati

For efficient inherently safe design, awareness of all available options at the appropriate decision-making moment is key. Simulations offer both timely availability and large screening possibilities. Therefore computer-aided product design gained in popul ...

Aidic Servizi Srl2016

Screening out irrelevant cell-based models of disease

Gerardo Turcatti

The common and persistent failures to translate promising preclinical drug candidates into clinical success highlight the limited effectiveness of disease models currently used in drug discovery. An apparent reluctance to explore and adopt alternative cell ...

Nature Publishing Group2016

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