Hémisynthèse

Applied sciences
Health sciences
Pharmacologie
Drug discovery

Publications associées (26)

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Reversible attachment of Cell-Penetrating Peptides for the efficient delivery of α-synuclein to HeLa cells and primary cortical neurons

Carole Desobry

The discovery of alpha-synuclein (a-syn) as the main component of Lewy Bodies (LBs), the pathological hallmarks of Parkinson's disease (PD), and the identification of mutations in the gene coding for a-syn in familial form of PD have reinforced the central ...

EPFL2014

Phage selection of bicyclic peptides

Christian Heinis, Inmaculada Rentero Rebollo

Bicyclic peptides are small, constrained peptides that can bind with high affinity and selectivity to protein targets. Their small size provides a number of advantages over larger protein-based ligands, including access to chemical synthesis, better tissue ...

Academic Press Inc Elsevier Science2013

Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies

Hilal Lashuel, Bruno Claude Daniel Fauvet, Marc Moniatte, Adrian Schmid

The development of novel therapies against neurodegenerative disorders requires the ability to detect their early, presymptomatic manifestations in order to enable treatment before irreversible cellular damage occurs. Precocious signs indicative of neurode ...

Amer Soc Biochemistry Molecular Biology Inc2013

Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix

Matthias Lütolf, Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez, Adrian Ranga

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-binding domain. Here we hypothesized that fibrin, the provisional ECM d ...

National Academy of Sciences2013

A Simple Synthetic Route to Obtain Pure Trans-Ruthenium(II) Complexes for Dye-Sensitized Solar Cell Applications

Michael Graetzel, Mohammad Khaja Nazeeruddin, Jun Ho Yum, Davide Di Censo, Filippo de Angelis, Guido Viscardi

We report a facile synthetic route to obtain functionalized quaterpyridine ligand and its trans-dithiocyanato ruthenium complex, based on a microwave-assisted procedure. The ruthenium complex has been purified using a silica chromatographic column by prote ...

Wiley-VCH Verlag Berlin2013

Reducing recombination in ZnO photoanodes for dye sensitised solar cells through simple chemical synthesis

Michael Graetzel, Vincent Laporte, Lioz Etgar

A method has been developed to synthesise zinc oxide nanowire arrays that demonstrate superior device performance compared to conventional ZnO nanowires within dye sensitised solar cells (DSSCs). This simple yet effective methodology has produced nanowires ...

Royal Society of Chemistry2012

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125

Hilal Lashuel, Michel Prudent, Bruno Claude Daniel Fauvet, Mirva Hejjaoui, Filip Vercruysse, Yao Zhang

Despite increasing evidence that supports the role of different post-translational modifications (PTMs) in modulating α-synuclein (α-syn) aggregation and toxicity, relatively little is known about the functional consequences of each modification and whethe ...

2012

Access to long-chain polyketides by double-elongation reactions : the AB and CD spiroacetals of the spongistatins

Christopher Flowers

Due to the spongistatins' fascinating and complex molecular architectures, and their important biological activities, these marine macrolides have been the subject of intensive efforts directed towards their total synthesis. As an attractive alternative to ...

EPFL2010

A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose

Pierre Vogel, Sandrine Gerber, Claudia Bello

The ketonitrone 8 was prepared from D-fructose as an inexpensive starting material, and was used in a stereoselective synthesis of 1-deoxymannojirimycin (4), its previously unknown N-hydroxy analogue 15, as well as the polyhydroxylated ketonitrone 14. The ...

2009

Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806

Cyril Portmann, Karl Gademann

Two new modified hexacyclopeptides, aerucyclamides A and B, were isolated from the toxic freshwater cyanobacterium Microcystis aeruginosa PCC 7806. The constitution was assigned by spectroscopic methods, and the configuration determined by chemical degrada ...

2008

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