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Publications associées (344)

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

Stewart Cole, Ruben Hartkoorn, Anthony Vocat, Jérémie Piton, Gaëlle Séraphine Kolly, Joao Pedro De Almeida Neres, Trent Michael Conroy

8-Nitro-benzothiazinones (BTZs), such as BTZ043 and PBTZ169, inhibit decaprenylphosphoryl-beta-D-ribose 2'-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro. Structure-activity relationship (SAR) studie ...

American Society for Microbiology2015

FULL SCALE TESTING OF EXTENDED BEAM-TO-COLUMN AND BEAMTO- GIRDER SHEAR TAB CONNECTIONS SUBJECTED TO SHEAR

Dimitrios Lignos

This paper discusses the findings of an experimental program that was conducted to investigate the behaviour of extended shear tab beam-to-column and beam-to-girder connections that are commonly used in North America. The laboratory results showed that ext ...

2015

Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome

Anamaria Necsulea

Long noncoding RNAs (lncRNAs) are one of the most intensively studied groups of noncoding elements. Debate continues over what proportion of lncRNAs are functional or merely represent transcriptional noise. Although characterization of individual lncRNAs h ...

Oxford Univ Press2015

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Carlos Canto Alvarez, Joanna Ratajczak, Pablo Jose Fernandez Marcos

Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...

Elsevier Science Bv2015

Tgfbi/Bigh3 silencing activates ERK in mouse retina

BIGH3 is a secreted protein, part of the extracellular matrix where it interacts with collagen and integrins on the cell surface. BIGH3 can play opposing roles in cancer, acting as either tumor suppressor or promoter, and its mutations lead to different fo ...

Academic Press Ltd- Elsevier Science Ltd2015

Assessment of metabolic fluxes in the mouse brain in vivo using (1)H-[(13)C] NMR spectroscopy at 14.1 Tesla

Rolf Gruetter, Lijing Xin, Hongxia Lei, Bernard Lanz

(13)C magnetic resonance spectroscopy (MRS) combined with the administration of (13)C labeled substrates uniquely allows to measure metabolic fluxes in vivo in the brain of humans and rats. The extension to mouse models may provide exclusive prospect for t ...

Nature Publishing Group2015

Structural and Functional Imaging of Pancreatic Islets using Optical Coherence Microscopy

Corinne Berclaz

In diabetes, pancreatic beta-cells play a key role. These cells are organized within structures called islets of Langerhans inside the pancreas and produce insulin. Insulin is one of the main hormones contributing to glucose homeostasis, which is the hallm ...

EPFL2015

Recapitulating De Novo Alpha-Synuclein Fibrillization in a Novel Neuronal Model of Parkinson's Disease

Mohamed Bilal Fares

Athough it has been established for over 100 years that Lewy bodies (LBs) represent the major pathological hallmark of Parkinson's disease (PD), we still do not know why these fibrillar intra-neuronal inclusions of the α-Synuclein (α-Syn) protein form, and ...

EPFL2015

Aeration Performances of a Gabion Stepped Weir with and without Capping

Davide Wüthrich

The stepped spillway design has been used for more than 3,300 years. A simple structure is the gabion stepped weir. A laboratory study was performed herein in a large size facility. Three gabion stepped weirs were tested with and without capping, as well a ...

Springer Verlag2015

The effects of stress during early postnatal periods on behavior and hippocampal neuroplasticity markers in adult male mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij

Infancy is a critical period for brain development. Emerging evidence indicates that stress experienced during that period can have long-term programming effects on the brain and behavior. However, whether different time periods represent different vulnera ...

2015

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