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Physcomitrella patens

Publications associées (25)

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Allogeneic dermal progenitor fibroblasts constitute cytotherapeutic contenders for modern cutaneous regenerative medicine. Based on advancements in the relevant scientific, technical, and regulatory fields, translational developments have slowly yet steadi ...

MDPI2023

Chinese Hamster Ovary [CHO] cells are the workhorse for production of modern biopharmaceuticals. They are however immortalized cells with a high propensity for genetic change. Judging from published culture records, CHO cell populations have undergone hund ...

2021

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Many real-time optimization schemes maximize process performance by performing a model-based optimization. However, due to plant-model mismatch, the model-based solution is often suboptimal. In modifier adaptation, measurements are used to correct the mode ...

IEEE2018

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In the context of static real-time optimization, the use of measurements allows dealing with uncertainty in the form of plant-model mismatch and disturbances. Modifier adaptation (MA) is a measurement-based scheme that uses first-order corrections to the m ...

IEEE2018

Industrial processes are run with the aim of maximizing economic profit while simultaneously meeting process-critical constraints. To this end, model-based optimization can be performed to ensure optimal plant operations. Usually, inevitable model inaccura ...

EPFL2018

The process industries are characterized by a large number of continuously operating plants, for which optimal operation is of economic and ecological importance. Many industrial systems can be regarded as an arrangement of several subsystems, where outp ...

EPFL2018

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Iterative real-time optimization schemes that employ modifier adaptation add bias and gradient correction terms to the model that is used for optimization. These affine corrections lead to meeting the first-order necessary conditions of optimality of the p ...

ELSEVIER SCIENCE BV2018

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In the context of real-time optimization, modifier-adaptation schemes use estimates of the plant gradients to achieve plant optimality despite plant-model mismatch. Plant feasibility is guaranteed upon convergence, but not at the successive operating point ...

Pergamon-Elsevier Science Ltd2017

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Model-based optimization methods suffer from the limited accuracy of the available process models. Because of plant-model mismatch, model-based optimal inputs may be suboptimal or, worse, unfeasible for the plant. Modifier adaptation (MA) overcomes this ob ...

Elsevier2016

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We discuss optimal load sharing of parallel gas compressors in the presence of plant-model mismatch. We formulate this problem as a static real-time optimization task and propose to tackle it by means of modifier adaptation. Under mild assumptions, the cho ...

Ieee2016

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