Publication
Optogenetic Probing of Cortical Synaptic Circuits Measured Through in Vivo Whole-Cell Recordings in the Mouse Barrel Cortex
Publications associées (211)
Excitation states of metabolic networks predict dose-response fingerprinting and ligand pulse phase signalling
Pierre Magistretti, Henry Markram, Felix Schürmann, Daniel Keller, Jay Coggan
With a computational model of energy metabolism in an astrocyte, we show how a system of enzymes in a cascade can act as a functional unit of interdependent reactions, rather than merely a series of independent reactions. These systems may exist in multipl ...
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2020Nanovolcano microelectrode arrays: toward long-term on-demand registration of transmembrane action potentials by controlled electroporation
Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles, Nicolas Grégoire Maïno, Stephan Rohr, Etienne de Coulon
Volcano-shaped microelectrodes (nanovolcanoes) functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access. These nanovolcanoes exhibit ...
2020Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose
Rolf Gruetter, Hongxia Lei, Bernard Lanz, Carole Poitry-Yamate, Antoine Timothée Cherix, Guillaume Donati, Blanca Lizarbe Serra
Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying (18) ...
2020Volcano-Shaped Scanning Probe Microscopy Probe for Combined Force-Electrogram Recordings from Excitable Cells
Philippe Renaud, Georg Fantner, Arnaud Bertsch, Mélanie Thérèse Marie Hannebelle, Benoît Xavier Emmanuel Desbiolles
Atomic force microscopy based approaches have led to remarkable advances in the field of mechanobiology. However, linking the mechanical cues to biological responses requires complementary techniques capable of recording these physiological characteristics ...
AMER CHEMICAL SOC2020Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex
Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova
The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...
FRONTIERS MEDIA SA2019In Silico Voltage-Sensitive Dye Imaging: A Model-Based Approach for Bridging Scales of Cortical Activity
An understanding of how microscale voltage fluctuations interact to shape mesoscale cortical information processing is lacking. Voltage-sensitive dye imaging (VSDI) is a powerful technique for interrogating membrane potential dynamics in assemblies of cort ...
EPFL2019Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex
Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Rodrigo de Campos Perin, Natali Barros Zulaica, Giuseppe Chindemi
Previous studies based on the 'Quantal Model' for synaptic transmission suggest that neurotransmitter release is mediated by a single release site at individual synaptic contacts in the neocortex. However, recent studies seem to contradict this hypothesis ...
2019A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology
Sameer Mohammad Khaleel Nazeeruddin
Tauopathies are neurodegenerative diseases whose common pathological feature is the intraneuronal accumulation of tau aggregates. Tau protein has various roles in the neuron, among which stabilization of microtubules (MT), regulation of synaptic activity o ...
EPFL2019Pathway-, layer- and cell-type-specific thalamic input to mouse barrel cortex
Carl Petersen, Berat Semihcan Sermet, Johannes Maria Mayrhofer
Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information, receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial (VPM) somatosensory thalamic nucleus most densely innervates layer 4 (L4) bar ...
ELIFE SCIENCES PUBLICATIONS LTD2019Metabolomics reveals tepotinib‐related mitochondrial dysfunction in MET activating mutations‐driven models
Genetic aberrations in the hepatocyte growth factor receptor tyrosine kinase MET induce oncogenic addiction in various types of human cancers, advocating MET as a viable anticancer target. Here, we report that MET signaling plays an important role in confe ...
2019