Mathematical Modeling of Brain Energy Metabolism, Measured with PET and MRS in Rodents
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The adult brain relies on glucose for its energy needs and stores it in the form of glycogen, primarily in astrocytes. Animal and culture studies indicate that brain glycogen may support neuronal function when the glucose supply from the blood is inadequat ...
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The range of applications of mathematical modelling in biosciences has recently expanded to encompass problems posed by biomedicine and sport sciences. Topics of interest are for instance the prediction of the response of an athlete to exercise, the pharma ...
BACKGROUND: For a long time now, glucose has been thought to be the main, if not the sole substrate for brain energy metabolism. Recent data nevertheless suggest that other molecules, such as monocarboxylates (lactate and pyruvate mainly) could be suitable ...
Ability to peer into human body is an essential diagnostic tool in medicine. Out of the four major imaging modalities that include ultra-sound, magnetic resonance imaging (MRI), and positron emission tomography (PET), nuclear medicine is gaining more wides ...
Magnetic resonance spectroscopy imaging (MRSI) is an attractive tool for medical imaging. However, its practical use is often limited by the intrinsic low spatial resolution and long acquisition time. Spectral localization by imaging (SLIM) has been propos ...
Institute of Electrical and Electronics Engineers2007
The brain of a hibernating mammal withstands physiological extremes that would result in cerebral damage and death in a non-hibernating species such as humans. To examine the possibility that this neuroprotection results from alterations in cerebral metabo ...
The measurement of brain activity in a noninvasive way is an essential element in modern neurosciences. Modalities such as electroencephalography (EEG) and magnetoencephalography (MEG) recently gained interest, but two classical techniques remain predomina ...
Institute of Electrical and Electronics Engineers2006
A novel approach for the mathematical modeling of (13)C label incorporation into amino acids via the TCA cycle that eliminates the explicit calculation of the labeling of the TCA cycle intermediates is described, resulting in one differential equation per ...
