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Optical Coherence Correlation Spectroscopy (OCCS)

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We present a 3D time-lapse imaging method for monitoring mitochondrial dynamics in living HeLa cells based on photothermal optical coherence microscopy and using novel surface functionalization of gold nanoparticles. The biocompatible protein-based biopoly ...

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Charles Baur, Sebastian Krzysztof Fifanski, José Luis Rivera Gutiérrez

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An original scheme for sensitive absorption measurements, particularly well-suited for low analyte concentrations, is presented. The technique is based on multiscattering-enhanced absorption spectroscopy (MEAS) and benefits from the advantages of conventio ...

Amer Chemical Soc2015

Optical Coherence Correlation Spectroscopy

Stéphane Broillet

Questions such as biomolecular interactions, kinetics of enzymes, DNA conformational changes, cellular structures properties (among others) are addressed by characterizing the biological function of molecules. This function depends on their structure and t ...

EPFL2014

Visible light optical coherence correlation spectroscopy

Theo Lasser, Heinrich Hofmann, Marcel Leutenegger, Arno Pino Bouwens, Lionel André Maurizi, Daniel Pawel Szlag, Stéphane Broillet

Optical coherence correlation spectroscopy (OCCS) allows studying kinetic processes at the single particle level using the backscattered light of nanoparticles. We extend the possibilities of this technique by increasing its signal-to-noise ratio by a fact ...

Optical Society of America2014

Optical Coherence Correlation Spectroscopy (OCCS)

Theo Lasser, Christophe Pache, Marcel Leutenegger, Arno Pino Bouwens, Stefan Geissbühler, Daniel Pawel Szlag, Akihiro Sato, Stéphane Broillet

A classical technique to monitor dynamical processes at the single-molecule level is fluorescence correlation spectroscopy (FCS). However, FCS requires fluorescent labels that are typically limited by photobleaching and saturation. We present a new method, ...

2013