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Comparative Performance of Different Nanostructured Electrochemical Sensors on Insulin Detection

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Background: The COVID-19 pandemic disrupted the delivery of diabetes care and worsened mental health among many patients with type 2 diabetes (T2D). This disruption puts patients with T2D at risk for poor diabetes outcomes, especially those who experience ...

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The counterregulatory response to hypoglycemia that restores normal blood glucose levels is an essential physiological function. It is initiated, in large part, by incompletely characterized brain hypoglycemia sensing neurons that trigger the secretion of ...

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IEEE2022

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

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Pancreatic beta-cells secrete insulin to lower blood glucose, following a meal. Maintenance of beta-cell function is essential to preventing type 2 diabetes. In pancreatic beta-cells, mitochondrial matrix calcium is an activating signal for insulin secreti ...

2020

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Rolf Gruetter, Hongxia Lei

Hypoglycemia is critical condition during diabetic treatment that involves intensive insulin therapy, and it may impair brain function. We aimed to compare cortical responses of three hypoglycemic phases and the restoration of glycemia to control levels af ...

2020

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Catherine Dehollain, Umberto De Marchi, Bakul Jitendra Vinchhi, Nicolas Bouche, Christophe Boss, Ninad Dilip Agashe

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

IEEE2019

Modeling and performance investigation of insulin injection pen for diabetic persons

Catherine Dehollain, Maria-Alexandra Paun

This paper is focused on modeling and performance investigation of insulin injection pens used by diabetic persons. A smart pen cap with two electrodes is used as a capacitive sensor for insulin dose detection and is presented in details. To faithfully ana ...

IEEE2019

Decoding Neural Metabolic Markers From the Carotid Sinus Nerve in a Type 2 Diabetes Model

Silvestro Micera

Recent studies showed that the carotid sinus nerve (CSN) and the sympathetic nervous system (SNS) are overactivated in type 2 diabetes and that restoring the correct CSN neural activity can re-establish the proper metabolism. However, a robust characteriza ...

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