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Neural and muscular factors both contribute to plantar-flexor muscle weakness in older fallers

Publications associées (35)

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Hybrid peripheral-spinal neuroprosthesis for refined motor execution after paralysis

Sophie Marie Marthe Wurth

Spinal cord injury (SCI) disrupts the communication between the brain and the spinal circuits responsible for movement, thereby causing severe motor deficits. Current strategies to restore function to paralyzed limbs have separately investigated electrical ...

EPFL2018

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Proprioceptive signals are a critical component of our ability to perform complex movements, identify our posture and adapt to environmental changes. Our movements are generated by a large number of muscles and are sensed via a myriad of different receptor ...

2018

A Computational Framework for the Design of Spinal Neuroprostheses

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Marco Capogrosso

Severe Spinal Cord Injury (SCI) alters the communication between supra-spinal centers and the sensorimotor networks coordinating limb movements, which are usually located below the injury. Epidural electrical stimulation of lumbar segments has shown the ab ...

Springer International Publishing Ag2017

Background: Previous studies have shown that a cerebrovascular accident disrupts the coordinated control of leg muscles during locomotion inducing asymmetric gait patterns. However, the ability of muscle synergies and spinal maps to reflect the redistribut ...

Biomed Central Ltd2015

[Neuronal control of posture and locomotion in decerebrated and spinalized animals]

Grégoire Courtine, Pavel Musienko

We have found that the brainstem-spinal cord circuitry of decerebrated cats actively maintain the equilibrium during standing, walking and imposed mechanical perturbations similar to that observed in intact animals. The corrective hindlimb motor responses ...

2013

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler, Janine Beauparlant

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord. We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell li ...

Nature Publishing Group2013

Experimental changes in bodily self-consciousness are tuned to the frequency sensitivity of proprioceptive fibres

Olaf Blanke, Jane Aspell, Estelle Palluel

Several lines of evidence suggest an important implication of proprioceptive signals in bodily self-consciousness. By manipulating proprioceptive signals using muscle vibration, here, we investigated whether such effects depend on the vibration frequency b ...

2012

Segmentation of Foot and Ankle Complex based on Kinematic Criteria

Kamiar Aminian, Julien Favre, Brigitte Jolles-Haeberli, Xavier Crevoisier, Hossein Rouhani

Although various foot models were proposed for kinematics assessment using skin makers, no objective justification exists for the foot segmentations. This study proposed objective kinematic criteria to define which foot joints are relevant (dominant) in sk ...

Taylor & Francis2011

Phase-dependent modulation of monosynaptic reflexes has been reported for several muscles of the lower limb of uninjured rats and humans. To assess whether this step-phase-dependent modulation can be mediated at the level of the human spinal cord, we compa ...

2010