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Of mice and men: Increased dendritic complexity gives rise to unique human networks

Publications associées (32)

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Layer, cell-type and pathway-specific thalamocortical input to mouse somatosensory cortex

Berat Semihcan Sermet

In the mouse whisker system, sensory information is relayed to the whisker somatosensory cortex by two major thalamic nuclei, the ventral posterior medial nucleus (VPM) and the posterior medial nucleus (POM). While the cortical axonal innervation pattern o ...

EPFL2018

Towards a theory of cortical columns: From spiking neurons to interacting neural populations of finite size

Wulfram Gerstner, Tilo Schwalger, Moritz Deger

Neural population equations such as neural mass or field models are widely used to study brain activity on a large scale. However, the relation of these models to the properties of single neurons is unclear. Here we derive an equation for several interacti ...

Public Library of Science2017

In the mammalian brain, sensory cortices exhibit plasticity during task learning, but how this alters information transferred between connected cortical areas remains unknown. We found that divergent subpopulations of cortico-cortical neurons in mouse whis ...

Nature Publishing Group2015

The cortex encodes a broad range of inputs. This breadth of operation requires sensitivity to weak inputs yet non-saturating responses to strong inputs. If individual pyramidal neurons were to have a narrow dynamic range, as previously claimed, then stagge ...

Oxford Univ Press Inc2015

Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron

Henry Markram, Srikanth Ramaswamy

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied neuron types in the mammalian neocortex and has become a benchmark for understanding information processing in excitatory neurons. By virtue of having the widest local ...

Frontiers Research Foundation2015

Motor Control in the Mouse Whisker System

Varun Sreenivasan

The motor systems of the mammalian brain are a remarkable product of many millions of years of evolution. It is the motor systems that make us and other mammals mobile, that guide our actions in response to sensory information and conversely modulate the v ...

EPFL2015

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

Michele Giugliano

Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than roden ...

Public Library Science2014

The In-Silico Neocortical Microcircuit

Michael Reimann

The neocortex is one of the most important brain regions, occupying more than 80% of the brain volume in mammals and contributing massively to its capability of perceiving and interpreting then environment. While it has been extensively studied, it is stil ...

EPFL2014

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

Carl Petersen, Sylvain Crochet

Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory glutamatergic and inhibitory GABAergic inputs. New optical, electrophysiological, and genetic methods allow detailed in vivo investigation of the superficia ...

Cell Press2013

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

Liliane Glauser, Elpida Tsika, Darren Moore, Sarah Catherine Sonnay, Klodjan Stafa, Alzbeta Trancikova, David Ramonet Jimenez, Agata Podhajska

Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an uncharacterized protein belonging to the P-5-type ATPase subfamily that is predicted to regulate t ...

Oxford University Press2012