Azidation of beta-Keto Esters and Silyl Enol Ethers with a Benziodoxole Reagent

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Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate

Arnaud Comment, Josefina Adriana Maria Bastiaansen

Cardiac dysfunction is often associated with a shift in substrate preference for ATP production. Hyperpolarized (HP) (13)C magnetic resonance spectroscopy (MRS) has the unique ability to detect real-time metabolic changes in vivo due to its high sensitivit ...

Nature Research2016

Characterization of hepatic fatty acids in mice with reduced liver fat by ultra-short echo time (1) H-MRS at 14.1 T in vivo

Rolf Gruetter, Hongxia Lei, Ana Francisca Leal Silva Soares

Alterations in the hepatic lipid content (HLC) and fatty acid composition are associated with disruptions in whole body metabolism, both in humans and in rodent models, and can be non-invasively assessed by (1) H-MRS in vivo. We used (1) H-MRS to character ...

Wiley-Blackwell2015

Conversion of chitin derived N-acetyl-D-glucosamine (NAG) into polyols over transition metal catalysts and hydrogen in water

Felix Daniel Bobbink, Ning Yan, Xi Chen

N-Acetyl-D-glucosamine (NAG), the monomer of the world's second most abundant biopolymer chitin, has been for the first time converted to its corresponding amide/amino substituted sugar alcohols, smaller C2-4 polyols and N-acetylmonoethanolamine (NMEA), ov ...

Royal Soc Chemistry2015

Rhodium(III)/Copper(II)-Promoted trans-Selective Heteroaryl Acyloxylation of Alkynes: Stereodefined Access to trans-Enol Esters

Nicolai Cramer, Van Manh Pham

Enol esters are versatile synthetic building blocks which can be elaborated by a wide variety of transformations. The classical synthesis by O-selective enolate acylation often hampers control of the E/Z selectivity with highly substituted substrates. A rh ...

Wiley-Blackwell2014

Regulation of Energy Metabolism and Mitochondrial Function in Skeletal Muscle During Lipid Overfeeding in Healthy Men

Context/Objective: The aim of this study was to evaluate the regulation of the fuel partitioning and energy metabolism in skeletal muscle during lipid overfeeding in healthy men. Design/Participants/Intervention: Thirty-nine healthy volunteers were overfed ...

Endocrine Soc2014

In vivo metabolic studies in skeletal and cardiac muscle using ¹³C magnetic resonance spectroscopy

Josefina Adriana Maria Bastiaansen

Cardiac and skeletal muscle function relies on a continuous energy production via fatty acid metabolism and mitochondrial oxidation of pyruvate, with a fine balance between substrate delivery and utilization. Changes in metabolism are increasingly being im ...

EPFL2013

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

Pierre Magistretti, Sylvain Eric Lengacher, Luc Pellerin

The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues. Genetically modified C57BL/6J mice were produced by targeted disruption of the mct1 gene in order to understand the ...

Public Library of Science2013

The effect of deposition power on the electrical properties of Al-doped zinc oxide thin films

Santiago Serrano Guisan

We investigated the effect on the electronic properties of aluminum (Al)-zinc oxide (ZnO) films by modulating the radio frequency sputtering power. Our experimental results show that increasing the sputtering power increases the Al doping concentration, de ...

AIP American Institute of Physics2010

Plate for matrix-assisted laser desorption ionization mass spectrometry, comprises electroconductive substrate covered with sintered nanoparticles, deposited as array of spots, for supporting ionization of sorbed sample molecules

Hubert Girault, Niels Erik Lion, Christophe Roussel, Liang Qiao, Michel Prudent, Jingjing Wan

NOVELTY - A plate comprises an electroconductive substrate (1) at least partially covered with sintered nanoparticles (2), deposited as an array of individual spots, for use as a sorbing phase for a sample, and for supporting ionization of sorbed sample mo ...

2009

EBSD: a powerful microstructure analysis technique in the field of solidification

Michel Rappaz, Emmanuelle Boehm Courjault, Alain Jacot, Mario Alberto Salgado Ordorica, Aurèle Mariaux, Christoph Niederberger

This paper presents a few examples of the application of electron back-scatter diffraction (EBSD) to solidification problems. For directionally solidified Al-Zn samples, this technique could reveal the change in dendrite growth directions from < 100 > to < ...

2009

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