Catalytic Reactions: Mannich and Strecker Pathways

This lecture covers the Mannich reaction, focusing on the choice of R group to modulate activation and catalyst release, and the Strecker reaction using Jacobsen urea catalyst for asymmetric catalysis. It also delves into the Aza-Friedel Craft reaction for tetracyclic systems and the catalytic reductive amination via dynamic kinetic resolution. Additionally, it explores extensions of carbonyl reactions, such as the activation of carbonyles for ene reaction, and the use of chiral oxazaborolidones in conjugate addition. The lecture concludes with the Diels Alder cycloaddition, covering both normal and inverse electron-demand scenarios.