Genetic Dosage and Chromosome Abnormalities

This lecture discusses the importance of genetic dosage, focusing on Trisomy 21 and its impact on protein concentration. It also covers the differences in protein production between men and women due to X chromosome inactivation, as well as the formation and significance of Barr bodies. The lecture further explores the genetic abnormalities associated with Triple X syndrome and the implications of such conditions on individuals, illustrated by the case of Ewa Klobukowska, an Olympic athlete. Various genetic concepts related to chromosome 21, electrophoresis, and X-inactivation are explained with examples and diagrams.