This lecture covers the concepts of entropy and Gibbs energy in thermodynamics. It explains the direction of spontaneous reactions, the increase in disorder of a system, and the relationship between entropy and temperature. The lecture also delves into the second and third principles of thermodynamics, microscopic definitions of entropy, and the standard molar entropies in reactions. Furthermore, it discusses the prediction of reaction spontaneity, the Gibbs free energy, and the combination of standard free enthalpies of formation in chemical reactions. The impact of temperature on spontaneity and practical applications in the kitchen are also explored.