Organoid Mechanobiology

This lecture explores the concept of multicellularity, differentiation of stem cells into various cell types, the formation of organoids from different tissues, and the applications of organoids in studying diseases, drug testing, and personalized medicine. It delves into the development and characteristics of brain, skin, and heart organoids, as well as the potential of gastruloids in self-organization. The lecture also covers the engineering of intestinal organoids, the formation of crypts, and the role of traction force microscopy in studying crypt dynamics. Furthermore, it discusses the next-generation engineered organoids, methods to engineer tissues, and the concept of organ-on-a-chip for mimicking organ functions in microfluidic devices.