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This lecture covers the energetic principles of molecular interactions in biomolecules, focusing on noncovalent interactions that govern the interactions between molecules. It delves into the atomic and macromolecular interactions, emphasizing van der Waals and hydrogen bonds. The discussion extends to the 3D structure of nucleic acids, highlighting the potential interaction sites and the key role of DNA and RNA as informational polymers in the cell. The lecture also explores the classification and characteristics of amino acids, the synthesis of proteins, and the hierarchical organization of protein structures.