Cross coupling of non-activated alkyl halides is a potentially transformative methodology in organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of non-activated alkyl halides. The current understanding of the mechanism of these coupling reactions is highlighted. As the mechanism is ligand-dependant, the perspective is organized according to the types of ligands employed in the catalysis.
Auke Ijspeert, Jonathan Patrick Arreguit O'Neill, Simon Lukas Hauser, Matthieu Guillaume Marie Dujany
Jean-Philippe Ansermet, Marcin Bialek
Michael Graetzel, Dan Ren, Yelin Hu, Jun Li, Reza Zamani, Xiaoyan Wang, Ziyun Wang, Yi Xu