Unit
Prof. Huelsken Group
LaboratorySummary
The Unite du Prof. Huelsken, led by Associate Professor Joerg Huelsken, focuses on investigating the mechanistic and therapeutic implications of the Cancer Stem Cell concept. The lab is dedicated to identifying targetable mechanisms of cancer progression, developing new approaches in immunotherapy to eradicate tumors by targeting Cancer Stem Cells, and studying mouse models of various cancers with an emphasis on metastatic disease. Research topics include niche induction, stromal reprogramming, immune evasion, and the development of microfluidic platforms for the analysis of Cancer Stem Cells.
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Related people (7)
Related publications (41)
Tumor-educated Gr1+CD11b+cells drive breast cancer metastasis via OSM/IL-6/JAK-induced cancer cell plasticity
Nadine Fournier, Manon Bulliard, Annamaria Kauzlaric, Yu-Ting Huang, Rachel Marcone
Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underl ...
Amer Soc Clinical Investigation Inc2024Immunosuppressive roles of Activin-A in melanoma and characterization of its precursor cleavage
Activin-A, a transforming growth factor êµ family member, is a pleiotropic cytokine with diverse functions in development, fertility, adult tissue homeostasis, and aging. Accordingly, deregulation of Activin-A signaling has been associated with many patho ...
EPFL2022The role of eosinophils in breast cancer
Eosinophils are granulocytes and belong to the innate arm of immunity. Eosinophils can be in different basal or activation states and depending on which type of activation is applied, they exert different effector functions. These multi-functional cells ha ...
EPFL2022