Dental implant

A dental implant (also known as an endosseous implant or fixture) is a prosthesis that interfaces with the bone of the jaw or skull to support a dental prosthesis such as a crown, bridge, denture, or facial prosthesis or to act as an orthodontic anchor. The basis for modern dental implants is a biological process called osseointegration, in which materials such as titanium or zirconia form an intimate bond to the bone. The implant fixture is first placed so that it is likely to osseointegrate, then a dental prosthetic is added. A variable amount of healing time is required for osseointegration before either the dental prosthetic (a tooth, bridge, or denture) is attached to the implant or an abutment is placed which will hold a dental prosthetic/crown. Success or failure of implants depends primarily on the thickness and health of the bone and gingival tissues that surround the implant, but also on the health of the person receiving the treatment and drugs which affect the chances of

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Dental restoration

Dental restoration, dental fillings, or simply fillings are treatments used to restore the function, integrity, and morphology of missing tooth structure resulting from caries or external trauma as we

Osseointegration

Osseointegration (from Latin osseus "bony" and integrare "to make whole") is the direct structural and functional connection between living bone and the surface of a load-bearing artificial implant ("

Bone grafting

Bone grafting is a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly.

Chemical functionalization of ceramics biomaterials for the development of new bone implants

Suradech Singhanat

2009

Numerical model of Total Knee Replacement replicating chair rising

Tshahé Auria Anongba Varela

Although the procedure of total knee replacement (TKR) has been improved for the last decades, patients may still face postoperative complications. Specially, causes of complications related to patellar resurfacing, such as osteonecrosis, patellar bone fracture, anterior knee pain and implant failure, are still unclear. Predicting strain state of the patellar bone after TKR by means of numerical modeling may help in understanding and possibly preventing such complications. First TKR model has been already developed within LBO (built in Abaqus/Standard). The model replicates loaded squat movement (Oxford rig). As the model is planned to be applied to the real TKA patients and compared with their real kinematics, squat movement could be problematic to accomplish for these patients. Thus we want also ask them to perform chair rising movement. In the project we propose to extend existing model of squat to “chair rising” movement. First, the student should study existing in vivo studies of chair rising to estimate kinematics during the movement. And then to implement this movement in Abaqus. The aim is to estimate patellar bone strain during this movement.

2014

Influence of TECK on chondrocyte differentiation

Benjamin David

Nowadays, cartilage repair is a worldwide centre of interest due to the low potential of cartilage to heal spontaneously and the increasing number of patients around the world. One of the techniques to treat cartilage defect is to use autologous human serum in cell-free implants to recruit chondrocytes. However, the serum is variable in its quality and therefore the chemokine TECK might be used as a reliable bioactive pharmaceutical component to recruit chondrocytes in cartilage regeneration techniques. In this study, the influence of the chemokine TECK on chondrocytes re-differentiation was studied during early chondrogenesis. So, high-density pellets were formed from three donors and cultivated for two and four days in three different concentrations of TECK, 0 [nM], 10 [nM] and 1000 [nM]. The high-density pellets were compared and analyzed at the protein and mRNA levels. Indeed, proteoglycans and type II collagen were stained to reveal the production of these two essential markers of chondrogenesis and RT-PCR was performed to evaluate the mRNA expression levels of various genes, type II collagen, type IX collagen, aggrecan, Sox 9, COMP, MMP 13 and Timp 1-2. It resulted that chondrocytes of two out of three donors showed a potential to re-differentatiate. In fact, these two donors increased their productions of proteolycans and type II collagen between day two and day four, a lapse of time considered as early chondrogenesis. These results were confirmed by the mRNA expression levels, which indicated increases of the expression levels in type II collagen, type IX collagen, aggrecan and Sox 9. Thus, the chemokine TECK showed no evidence that it modified the behaviours of chondrocytes in high-density pellets during the first four days. So, TECK might be a reliable bioactive pharmaceutical component to recruit chondrocytes in order to regenerate cartilage in the future

2010

MSE-471: Biomaterials (pour MX)

The course introduces the main classes of biomaterials used in the biomedical field. The interactions with biological environment are discussed and challenges highlighted. State of the art examples per type of material are discussed. Students will generate a biomaterial and study cell compatibility.

BIOENG-448: Fundamentals of neuroengineering

Neuroengineering is at the frontier between neuroscience and engineering: understanding how the brain works allows developing engineering applications and therapies of high impact, while the design of new measurement and data analysis techniques contributes to advance our knowledge about the brain.

ME-482: Biomechanics of the musculoskeletal system

The basis for a mechanical description of the musculoskeletal system are presented. This description is based on the concepts of solid mechanics, physiology and anatomy of the musculoskeletal system. Concrete examples of the development of implants are also covered.