Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all parts of the bodies of bilaterally symmetric and triploblastic animals—that is, all multicellular animals except sponges and diploblasts. It is a structure composed of nervous tissue positioned along the rostral (nose end) to caudal (tail end) axis of the body and may have an enlarged section at the rostral end which is a brain. Only arthropods, cephalopods and vertebrates have a true brain, though precursor structures exist in onychophorans, gastropods and lancelets. The rest of this article exclusively discusses the vertebrate central nervous system, which is radically distinct from all other animals. In vertebrates, the brain and spinal cord are both enclosed in the meninges. The meninges provide a barrier to chemicals dissolved in the blood, protecting the brain from most neurotoxins commonly found in food. Within the meninges the brain and spinal cord are bathed in cerebral spinal fluid which replaces the body fluid found outside the cells of all bilateral animals. In vertebrates, the CNS is contained within the dorsal body cavity, while the brain is housed in the cranial cavity within the skull. The spinal cord is housed in the spinal canal within the vertebrae. Within the CNS, the interneuronal space is filled with a large amount of supporting non-nervous cells called neuroglia or glia from the Greek for "glue". In vertebrates, the CNS also includes the retina and the optic nerve (cranial nerve II), as well as the olfactory nerves and olfactory epithelium. As parts of the CNS, they connect directly to brain neurons without intermediate ganglia. The olfactory epithelium is the only central nervous tissue outside the meninges in direct contact with the environment, which opens up a pathway for therapeutic agents which cannot otherwise cross the meninges barrier.

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation