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Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.
Covers the decline of cancer death rates, conventional and targeted anticancer drugs, surgical oncology, radiotherapy, chemotherapy, resistance mechanisms, and the history of targeted drugs and EGFR targeting.
Explores how inflammation promotes tumor growth and immunosuppression, focusing on the role of inflammatory cells like MDSCs and neutrophils in the tumor microenvironment.
