Protein Induced Degradation: Druggability Strategy

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Bacterial AAA+ Protease: Activity Control and Toxic Deregulation

Explores the activity control and toxic deregulation of a bacterial AAA+ protease, focusing on the role of AAA+ machines in protein quality control.

Protein Quality Control of Membraneless Organelles

Explores protein quality control in membraneless organelles and its implications for diseases.

Identifying Correct Target in Medical Chemistry

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Post-translational regulation of ER proteostasis

Explores the post-translational regulation of ER proteostasis, focusing on BiP chaperone activity, ER stress response, and FICD-mediated AMPylation.

Drug Development and Ethical Principles

Explores the historical aspects of drug development, regulatory agencies, and ethical principles in pharmacology, emphasizing the importance of informed consent and human subject protection.

BiP-mediated ER quality control: assists and hurdles

Delves into BiP-mediated ER quality control, addressing protein folding, degradation, and unique challenges in B cell development.

Protein-Ligand Interactions

Explores the principles of protein-ligand interactions, covering methods for measuring affinity and kinetics in drug development.

DNA Replication: Sister Chromatids Cohesion

Explores DNA replication in eukaryotes and the cohesion of sister chromatids.

Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Total Synthesis: Strategies and Impact

Explores total synthesis of natural products, strategies, impact on science and society, drug development, and biological studies.