This lecture introduces model predictive control (MPC) for multi-region Macroscopic Fundamental Diagrams (MFDs) in traffic flow modeling. The instructor explains the transition from single to multi-region control logic, the benefits of MPC in handling non-linear control problems and state constraints, and the application of MPC in different MFD systems. The lecture covers the formulation and results of MPC in a two-region MFD system, addressing errors in MFDs and biased demand/control smoothing. Additionally, it discusses the coordinated control of a mixed freeway-arterial network to minimize total delay, including the system characteristics, formulation, and performance comparison of different controllers.