Designing Targeted Protein Degraders

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Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.

Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

Frontiers in Chemical Biology

Explores the druggable proteome, PROTACS strategy, ubiquitin attachment, and drug development paradigms.

Protein Function Regulation: Degradation Mechanisms

Covers the mechanisms of protein degradation, including the roles of the proteasome and autophagy in regulating protein function.

Protein Induced Degradation: Druggability Strategy

Explores protein-induced degradation to enhance target druggability and the use of PROTACS in drug development.

PROTACs: Catalytic Protein Knockdown Strategy

Explores PROTACs, a catalytic protein knockdown strategy with potential in tumor treatment and drug development.

Protein Modifications: Ubiquitination and Acylation

Explores protein modifications through ubiquitination, acylation, and Ras acylation importance.

Ubiquitination: Protein Degradation

Explores ubiquitination, protein degradation, and cellular regulation through ubiquitin tagging, covering various cellular processes and pathways.

Membrane Protein Quality Control at ER

Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.

DNA Replication: Sister Chromatids Cohesion

Explores DNA replication in eukaryotes and the cohesion of sister chromatids.