Explores p53's pivotal role in cellular stability, DNA repair, and tumor suppression, emphasizing TP53 mutations and DNA double-strand break repair mechanisms.
Explores DNA repair mechanisms, including BER, MMR, NER, and repair of double-strand breaks, as well as the impact of UV-induced lesions and resistance to PARP inhibitors.
Explores the genetic mechanisms of retinoblastoma and their clinical implications, shedding light on tumor suppression, DNA repair, and genetic recombination.
Covers DNA damage types, repair mechanisms, UV-induced damage, survival curves, NER deficiency consequences, tumor suppressor genes, and cancer prevention.
