Receptor Tyrosine Kinases: Signalling and Regulation

This lecture covers the structure and function of receptor tyrosine kinases (RTKs), focusing on their activation through ligand binding, dimerization, and phosphorylation. It explores the downstream signalling cascades initiated by RTKs and the regulatory mechanisms involved. The lecture also discusses the implications of RTK dysregulation in diseases such as cancer, highlighting the potential therapeutic strategies targeting RTKs. Additional topics include the auto-inhibition mechanisms and the pharmaceutical approaches for targeting RTKs. Further reading suggestions are provided for a deeper understanding of RTK biology.