Protein Phosphorylation: Mechanisms and Regulation

This lecture provides an overview of post-translational modifications, focusing on phosphorylation. It covers the chemical modifications of amino acids, the most common types of phosphorylation, and the structural effects of phosphorylation in proteins. The lecture also discusses the importance of phosphorylation in signaling, enzyme regulation, and transcription factor activation. Furthermore, it delves into the activity and regulation of protein kinases, the human kinome, and the role of tyrosine phosphorylation. The lecture concludes with insights into kinase specificity, kinase pathways, and the implications of aberrant kinase activation in diseases like cancer.