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Explores the mechanisms of ALS, focusing on SOD1 pathology, including toxic gain of function, protein misfolding, ER stress, and mitochondrial dysfunction.
Explores protein aggregation in neurodegenerative diseases, emphasizing the need to rethink treatment strategies and understand the role of post-translational modifications.
Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.
Explores Tau pathologies in Alzheimer's and related disorders, covering hyperphosphorylation, propagation, genetic associations, and therapeutic interventions.
Explores the basic concepts and translational opportunities in immunometabolism, emphasizing the intricate interactions between immune cells and different cell types.
