Tyrosine Kinases & Ras Signaling

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Post-translational Modifications of Proteins

Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.

GPCRs: Molecular Endocrinology

Explores the structure and activation of 7TM receptors and the downstream effects of CAMP and protein kinase A.

Cellular Communication: Signaling Pathways and Receptors

Delves into the importance of intercellular communication and the diverse signaling pathways involved in cellular responses.

Insulin Receptor Activation: Signaling Mechanisms

Explains insulin receptor activation and cytokine receptor signaling mechanisms in detail.

Cancer Biology: Hallmarks and Mechanisms

Covers the hallmarks of cancer, oncogenes, tumor suppressor genes, metastasis, and genetic alterations driving tumorigenesis.

Altered Metabolism in Cancer: Warburg Effect and MYC Regulation

Explores altered cancer metabolism, MYC regulation, Rb and p53 pathways, AKT re-activation, and protein-protein interactions.

Evading Growth Suppression: TGFB Signaling

Explores how cells evade growth suppression, focusing on TGFB signaling and the role of tumor suppressors like PTEN and p53.

Kinase Inhibitors: Types and Mechanisms

Explores kinase inhibitors, their types, mechanisms, and experimental evaluation, emphasizing the significance of covalent drugs in modern pharmaceutical research.

Bacterial Signalling: Two-component Systems

Explores bacterial two-component signalling systems, gene regulation, chemotaxis, and flagellar rotation in E. coli.

SEGREGATION of KINETIC REACTIVITY & BINDING AFFINITY

The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance.