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Lecture
Are you an EPFL student looking for a semester project?
Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
The paper focuses on the importance of reversible interactions to potency and mechanisms of drug resistance. It discusses the systematic assessment of non-covalent binding and chemical reactivity components to the ultimate clinical potency of emerging covalent kinase drugs. The authors deconvolute contributions from the 'reversible' component of a covalent drug, and the assay readout is considered. The study evaluates the kinetic analysis of covalent inhibition of EGFR- L858R/T790M, a disease-relevant double mutant. The data shows the kinetic analysis of various inhibitors and their impact on EGFR mutants.