Drug-Induced Liver Injury (DILI): Mechanisms and Mitigation

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Drug-Induced Liver Injury: Mitigation Strategies

Explores Drug-Induced Liver Injury mechanisms, mitigation strategies, and challenges in drug development.

Drug Metabolism: Xenobiotics and Enzymes

Explores drug metabolism, focusing on xenobiotics, enzymes, biotransformation reactions, and factors affecting drug metabolism.

Pharmacokinetics: Drug Absorption and Distribution

Explores drug absorption, distribution, and clinical implications, focusing on salicylate poisoning and drug trapping in lysosomes.

Pharmacogenetics: Drug Response and Genetic Variability

Delves into pharmacogenetics, exploring genetic influences on drug response variability and metabolism.

Interrogating SAR in Medical Chemistry

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Identifying Correct Target in Medical Chemistry

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Selective Drug Targeting Mechanisms

Explores selective drug targeting mechanisms, resistance development, tuberculosis incidence, BCR-ABL mutations, tyrosine kinase inhibitors, drug toxicity, interactions, and toxicology studies.

Pharmacokinetic & Pharmacodynamic Evaluations

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Fragment-Based Drug Discovery: Concepts & Technologies

Covers the concepts and technologies of fragment-based drug discovery, exploring hit identification, lead optimization, and screening methods.