Telomere Syndromes: Molecular Mechanisms and Disease Implications

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Cellular Senescence and Tumor Progression

Explores cellular senescence, oncogene activation, DNA damage response, and telomere dysfunction in cancer suppression pathways.

Telomeres and Cancer

Explores telomeres' role in cancer biology, covering telomerase, replication problems, ALT pathway, and Nobel Prize-winning discoveries.

Replicative Immortality

Explores replicative immortality in cancer cells, focusing on telomere erosion, telomerase activity, and the role of p53 in maintaining genomic stability.

Proteostasis Regulation in C. elegans

Examines how a receptor regulates proteostasis in C. elegans, emphasizing the importance of maintaining cellular function and preventing protein misfolding diseases.

Protein Homeostasis Networks: Promoting Healthy Ageing

Explores manipulating protein networks to promote healthy ageing through stress responses and proteostasis maintenance.

Telomeres and Cancer

Explores telomeres' crucial role in cancer biology, covering telomerase, replication problems, ALT pathway, and TERRA functions.

Self-attraction of DNA: Mediated Interactions

Discusses the self-attraction of DNA and its mediated interactions.

DNA Structure and Function

Explores DNA structure, histone interactions, polymerase function, nucleosome organization, chromatin compaction, cell cycle phases, FISH analysis, and telomere structure.

Proteomics: Post-Translational Modifications and Interactions

Explores proteomics for post-translational modifications and protein interactions.

Cellular Senescence: Mechanisms and Implications

Explores cellular senescence mechanisms induced by mitogenic signals, DNA damage, and oncogenes, emphasizing the role of key regulatory proteins and the impact on cell division.