Genomic Imprinting: Disorders and Mechanisms

In course

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Description

This lecture discusses the importance of DNA methylation in genomic imprinting, focusing on cases of maternal and paternal uniparental disomy of chromosome 7. It explores the clinical manifestations of Silver-Russell syndrome and Angelman syndrome, highlighting the impact of imprinted genes on growth and neurological development. The molecular mechanisms behind monoallelic expression and the role of DNA methylation in regulating gene expression are also explained.

Instructor

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Official source