Synthesis of a model bicyclic C-O-D-O-E ring of vancomycin by a one-pot, double SNAr based macrocyclization
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Double cyclization of linear pentapeptide I by treatment with CsF in DMF at -5 Deg gives a model bicyclic (C)-O-(D)-O-(E) ring analog of vancomycin in a one step. [on SciFinder (R)]
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A utility bicycle, city bicycle, urban bicycle, European city bike (ECB), Dutch bike, classic bike or simply city-bike, is a bicycle designed for frequent very short, very slow rides through very flat urban areas. It is a form of utility bicycle commonly seen around the world, built to facilitate everyday short-distance riding (no more than 5-6 km a day) in normal clothes in cold-to-mild weather conditions.
A folding bicycle is a bicycle designed to fold into a compact form, facilitating transport and storage. When folded, the bikes can be more easily carried into buildings, on public transportation (facilitating mixed-mode commuting and bicycle commuting), and more easily stored in compact living quarters or aboard a car, boat or plane. Folding mechanisms vary, with each offering a distinct combination of folding speed, folding ease, compactness, ride, weight, durability, complexity and price.
A bicycle, also called a pedal cycle, bike, push-bike or cycle, is a human-powered or motor-powered assisted, pedal-driven, single-track vehicle, having two wheels attached to a frame, one behind the other. A is called a cyclist, or bicyclist. Bicycles were introduced in the 19th century in Europe. By the early 21st century there were more than 1 billion. These numbers far exceed the number of cars, both in total and ranked by the number of individual models produced. They are the principal means of transportation in many regions.
The motion of parts of an object is usually perceived relative to the object, i.e., nonretinotopically, rather than in retinal coordinates. For example, we perceive a reflector to rotate on the wheel of a moving bicycle even though its trajectory is cycloi ...
Association for Research in Vision and Ophthalmology (ARVO)2017
Bicycle-sharing systems stations are often imbalanced. Stations are said to be in excess when there is no empty dock for users willing to deposit their bicycle. Conversely, stations aresaidtobeinshortagewhenthereisnoavailablebicycle. Rebalancingcanbeachiev ...
More than 16, 000 people reach the EPFL campus every day by public transport, private car or non-motorised transports. According to the EPFL "Mobility Survey 2019", 22% of students commute by bicycle (compared to 20% of staff), but still 30% of the staff c ...
