Concept

Acide nucléique peptidique

Publications associées (60)

Synthesis of Pyrrolidinone PNA: A Novel Conformationally Restricted PNA Analogue

To preorganize PNA for duplex formation, a new cyclic pyrrolidinone PNA analog has been designed. In this analog the aminoethyl-glycine backbone and the methylene-carbonyl linker are connected, introducing two chiral centers compared to PNA. The four stere ...

2001

Methods of nucleic acid amplification and sequencing

Gerardo Turcatti

Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified or sequenced, wherein said nucleic acid(s) contains at the 5 ...

2000

Radiation damping compensation of selective pulses in water-protein exchange spectroscopy

Geoffrey Bodenhausen

The observation of nuclear Overhauser effects (NOEs) between bound water and biol. macromols. such as proteins and nucleic acids can be improved by inverting the water resonance selectively while compensating for radiation damping effects. The efficiency o ...

2000

Chemistry of Pyranosyl-RNA, Part 8. Opposite orientation of backbone inclination in pyranosyl-RNA and homo-DNA correlates with opposite directionality of duplex properties

A comparison of relevant properties of selected pyranosyl-RNA and homo-DNA duplexes offers an opportunity for testing the thesis of the predominant role of inter-strand base stacking in oligonucleotide systems with large backbone inclination. Missing base ...

1999

Functional molecular thin films: topological templates for the chemoselective ligation of antigenic peptides to self-assembled monolayers

Horst Vogel, Hans Jörg Mathieu

Chem. ligation methods in combination with regioselective addressable templates have allowed the prepn. of well defined complex monomol. films tethered to gold surfaces. The supramol. monolayers exposed artificial recognition sites, here for monoclonal ant ...

1999

A Highly Enantio-Selective Hexitol Nucleic Acid Template for Nonenzymic Oligoguanylate Synthesis

The authors compare the enantiomeric cross-inhibition of D- and L-guanosine 5'-phosphoro-2-methyl-imidazole (I) polymn. on C10 (RNA), dC10 (DNA), or hC10 (hexitol nucleic acid) (II). RNA or DNA templates catalyze efficient oligomerization of D-I, with a st ...

1999

Design of Oligonucleotide Arrays at Interfaces

Horst Vogel

The surface attachment and detection of DNA probes are essential in the design of nucleic acid-based biosensors. A new strategy for the covalent immobilization of single-stranded oligonucleotides on gold-covered planar supports is presented. Optimization o ...

1999

Antimicrobial peptide defense in Drosophila

Bruno Lemaitre

Drosophila responds to a septic injury by the rapid synthesis of antimicrobial peptides. These molecules are predominantly produced by the fat body, a functional equivalent of mammalian liver, and are secreted into the hemolymph where their concentrations ...

Wiley-Blackwell1997

Role of the Prp Gene in Transmissible Spongiform Encephalopathies

Michel Aguet

The transmissible agent that causes spongiform encephalopathies such as scrapie, the prion, is believed to be devoid of nucleic acid and identical with PrP(Sc), a modified form of PrP(C). PrP(C) is a normal host protein encoded by a single copy gene (Prn-p ...

1993

Imaging Lipid Metabolism at the Golgi Complex.

Giovanni D'Angelo

The development of fluorescence-based molecular imaging has revolutionized cell biology allowing the visualization of specific biomolecules at the microscopic and, more recently, at the nanoscopic scale while in their relevant biological contexts. Nonethel ...

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