Behavioural genetics, also referred to as behaviour genetics, is a field of scientific research that uses genetic methods to investigate the nature and origins of individual differences in behaviour. While the name "behavioural genetics" connotes a focus on genetic influences, the field broadly investigates the extent to which genetic and environmental factors influence individual differences, and the development of research designs that can remove the confounding of genes and environment. Behavioural genetics was founded as a scientific discipline by Francis Galton in the late 19th century, only to be discredited through association with eugenics movements before and during World War II. In the latter half of the 20th century, the field saw renewed prominence with research on inheritance of behaviour and mental illness in humans (typically using twin and family studies), as well as research on genetically informative model organisms through selective breeding and crosses. In the late 20th and early 21st centuries, technological advances in molecular genetics made it possible to measure and modify the genome directly. This led to major advances in model organism research (e.g., knockout mice) and in human studies (e.g., genome-wide association studies), leading to new scientific discoveries.
Findings from behavioural genetic research have broadly impacted modern understanding of the role of genetic and environmental influences on behaviour. These include evidence that nearly all researched behaviours are under a significant degree of genetic influence, and that influence tends to increase as individuals develop into adulthood. Further, most researched human behaviours are influenced by a very large number of genes and the individual effects of these genes are very small. Environmental influences also play a strong role, but they tend to make family members more different from one another, not more similar.
Selective breeding and the domestication of animals is perhaps the earliest evidence that humans considered the idea that individual differences in behaviour could be due to natural causes.
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Gene–environment correlation (or genotype–environment correlation) is said to occur when exposure to environmental conditions depends on an individual's genotype. Gene–environment correlations (or rGE) is correlation of two traits, e.g. height and weight, which would mean that when one changes, so does the other. Gene–environment correlations can arise by both causal and non-causal mechanisms. Of principal interest are those causal mechanisms which indicate genetic control over environmental exposure.
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Genes, Brain and Behavior ou G2B (en français, Gènes, cerveau et comportement, abrégé en Genes Brain Behav.) est une revue scientifique à comité de lecture dans les domaines de la génétique comportementale, neuronale et psychiatrique. D'après le Journal Citation Reports, le facteur d'impact de ce journal était de 4,061 en 2010. Le directeur fondateur est Wim E. Crusio (CNRS et université Bordeaux-I, France). L'actuel directeur de publication est Andrew Holmes (National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, États-Unis).
Explore les variantes de maladies communes vs rares, GWAS, les rapports de cotes, les valeurs P et l'héritabilité manquante dans les études génétiques.
Explore l'analyse des génotypes et des variants grâce à une étude d'association à l'échelle du génome, en se concentrant sur l'association entre les variants génétiques et les phénotypes comme la hauteur.
Animals, including humans, exhibit a remarkable variety of complex behaviours. How the nervous system controls all these behaviours ranging from simple, stereotyped movements to flexible, adaptive actions is a central questions of neuroscience. One of the ...
EPFL2024
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Background Children born very preterm (VPT;
SPRINGERNATURE2022
The estimation of genetic clusters using genomic data has application from genome-wide association studies (GWAS) to demographic history to polygenic risk scores (PRS) and is expected to play an important role in the analyses of increasingly diverse, large ...