The principle of indifference (also called principle of insufficient reason) is a rule for assigning epistemic probabilities. The principle of indifference states that in the absence of any relevant evidence, agents should distribute their credence (or 'degrees of belief') equally among all the possible outcomes under consideration.
In Bayesian probability, this is the simplest non-informative prior. The principle of indifference is meaningless under the frequency interpretation of probability, in which probabilities are relative frequencies rather than degrees of belief in uncertain propositions, conditional upon state information.
The textbook examples for the application of the principle of indifference are coins, dice, and cards.
In a macroscopic system, at least, it must be assumed that the physical laws that govern the system are not known well enough to predict the outcome. As observed some centuries ago by John Arbuthnot (in the preface of Of the Laws of Chance, 1692),
It is impossible for a Die, with such determin'd force and direction, not to fall on such determin'd side, only I don't know the force and direction which makes it fall on such determin'd side, and therefore I call it Chance, which is nothing but the want of art....
Given enough time and resources, there is no fundamental reason to suppose that suitably precise measurements could not be made, which would enable the prediction of the outcome of coins, dice, and cards with high accuracy: Persi Diaconis's work with coin-flipping machines is a practical example of this.
A symmetric coin has two sides, arbitrarily labeled heads (many coins have the head of a person portrayed on one side) and tails. Assuming that the coin must land on one side or the other, the outcomes of a coin toss are mutually exclusive, exhaustive, and interchangeable. According to the principle of indifference, we assign each of the possible outcomes a probability of 1/2.
It is implicit in this analysis that the forces acting on the coin are not known with any precision.